Antimicrobial Peptides (PDF)

Preface ANTIMICROBIAL PEPTIDES: THEIR HISTORY, EVOLUTION AND FUNCTIONAL PROMISCUITY Introduction: The History of AMPs AMPs: Evolutionarily Ancient Molecules AMPs: Multifunctional Molecules Discussion CATIONIC ANTIMICROBIAL PEPTIDES Introduction CAMPs and their Antimicrobial Action CAMPs that Adopt Alpha-Helical Structure CAMPs that Adopt Beta-Sheet Structures CAMPs that Adopt Extended Structures Rich in Specific Residues Discussion ANIONIC ANTIMICROBIAL PEPTIDES Introduction AAMPs in the Respiratory Tract AAMPs in the Brain AAMPs in the Epidermis AAMPs in Blood Components AAMPs in the Gastro-Intestinal Tract and Food Proteins AAMPs and their Strucutre / Function Relationships Discussion GRAPHICAL TECHNIQUES TO VISUALIZE THE AMPHIPHILIC STRUCTURES OF AMPS Introduction Amphiphilic Structures Adopted by AMPs Qualitative Methods for Identifying Amphiphilic Structure Quantitative Techniques for Analysing Amphiphilic Structure Discussion MODELS FOR THE MEMBRANE INTERACTIONS OF ANTIMICROBIAL PEPTIDES Introduction CM-Associated Factors that Effect the Antimicrobial Action of a Alpha-CAMPs Mechanisms Used by CAMPs for Microbial Membrane Interaction Established Models for the Membrane Interactions of Alpha-AMPs Recent Novel Models for the Membrane Interactions of Alpha-AMPs The Tilted Peptide Mechanism Amyloidogeneic Mechanisms Discussion THE SELECTIVITY AND TOXICITY OF ONCOLYTIC ANTIMICROBIAL PEPTIDES Introduction Peptide-Based Factors that Contribute to the Anticancer Action of ACPs Membrane-Based Factors that Contribute to the Anticancer Action of ACPs Discussion

Professor David Andrew Phoenix, OBE, AcSS, DSc studied Biochemistry at degree and doctoral level at Liverpool University which in 2009
awarded him a Doctor of Science for his impact on the field. In 2000 he was appointed Professor of Biochemistry, at the University of
Central Lancashire (UCLan) and has held visiting chairs in Canada and Russia. He has published over 150 papers as well as a number of
edited collections and monographs. He is a Fellow of the Royal Society of Chemistry, The Society of Biology, The Institute of Mathematics and Its Applications and the Royal Society of Medicine. Since 2008 he has been the Deputy Vice Chancellor of UCLan and also Chairs a research institute in Shenzhen focused on nanotechnology and biomedical engineering. He was made an Officer of the Most Excellent Order of the British Empire in 2010 for services to Science and Higher Education and recognized as an Academician by the Academy of Social Sciences in 2012.

Dr. Sarah Rachel Dennison PhD graduated from the University of Wales, Bangor with a Bachelor of Science in Environmental Biology in 1999. Subsequently, she undertook postgraduate research in Biochemistry / Biophysics, which led to a doctorate in 2004. Currently, Sarah is a Research Associate in the School of Pharmacy and Biomedical Sciences at UCLan where she is investigating the role of amphiphilicity
in the function of antimicrobial peptides using a number of biophysical techniques.

Dr. Frederick Harris PhD studied at UCLan, graduating with a Bachelor of Science in Biochemistry and Microbiology in 1993 before gaining his
Doctorate for work on the penicillinbinding proteins of Escherichia coli in 1998. Subsequently, he has undertaken research at Utrecht University
and the Leibniz-Centre for Medicine and Biosciences, Germany. In 2000, Frederick started as a Research Fellow at UCLan and now has more than 75 publications to his name, which primarily focus on antimicrobial and anticancer peptides.

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