Arrow-Pushing in Organic Chemistry (ePub)

Preface. Acknowledgments. About the Author. Chapter 1 Introduction. 1.1 Definition of Arrow Pushing. 1.2 Functional Groups. 1.3 Nucleophiles and Leaving Groups. 1.4 Summary. Problems. Chapter 2 Acids. 2.1 What are Acids? 2.2 What is Resonance? 2.3 How is Acidity Measured? 2.4 Relative Acidities. 2.5 Inductive Effects. 2.6 Inductive Effects and Relative Acidities. 2.7 Relative Acidities of Hydrocarbons. 2.8 Summary. Problems. Chapter 3 - Bases and Nucleophiles. 3.1 What are bases? 3.2 What are nucleophiles? 3.3 Leaving Groups. 3.4 Summary. Problems. Chapter 4 - SN2 Substitution Reactions. 4.1 What is an SN2 Reaction? 4.2 What are Leaving Groups? 4.3 Where can SN2 Reactions Occur? 4.4 SN2' Reactions. 4.5 Summary. Problems. Chapter 5 SN1 Substitution Reactions. 5.1 What is an SN1 Reaction? 5.2 How are SN1 Reactions Initiated? 5.3 The Carbocation. 5.4 Carbocation Rearrangements. 5.5 Summary. Problems. Chapter 6. Elimination Reactions. 6.1 E1 Eliminations. 6.2 E2 Eliminations. 6.3 How do Elimination Reactions Work? 6.4 Summary. Problems. Chapter 7 - Addition Reactions. 7.1 Addition of Halogens to Double Bonds. 7.2 Markovnikov's Rule. 7.3 Additions to Carbonyls. 7.4 Summary. Problems. Chapter 8-Moving Forward 8.1 Functional Group Manipulations. 8.2 Name Reactions. 8.3 Reagents. 8.4 Final Comments. Problems. Appendix 1-pKa Values of Protons Associated with Common Functional Groups. Appendix 2-Answers and Explanations to Problems. Chapter 1 Solutions. Chapter 2 Solutions. Chapter 3 Solutions. Chapter 4 Solutions. Chapter 5 Solutions. Chapter 6 Solutions. Chapter 7 Solutions. Chapter 8 Solutions. Appendix 3-Student Reaction Glossary. Index. Periodic Table of the Elements.

DANIEL E. LEVY, PhD, is the Director of Synthetic Chemistry at Intradigm Corporation, pursuing delivery vehicles for siRNA therapeutics. He previously worked at Glycomed Inc., where he pursued the design and synthesis of novel glycomimetics for the treatment of cancer and inflammatory disorders; COR Therapeutics, where he pursued carbocyclic AMP analogs as inhibitors of type V adenylyl cyclase; and at Scios, Inc., where he pursued novel kinase inhibitors. Dr. Levy coauthored a book entitled The Chemistry of C-Glycosides and later collaborated with Dr. Péter Fügedi in the development and presentation of short courses entitled "Modern Synthetic Carbohydrate Chemistry" and "The Organic Chemistry of Sugars" offered by the American Chemical Society Continuing Education Department. Most recently, Dr. Levy coedited with Dr. Fügedi the book The Organic Chemistry of Sugars, based on the short course of the same name. Dr. Levy received his BS in chemistry from the University of California, Berkeley, and his PhD in organic chemistry from the Massachusetts Institute of Technology.

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