Bursting Neurons and Fading Memories (ePub)

Dr. D'Andrea has a PhD in Cell and Developmental Biology and an MS in Molecular Biology. He has authored over 100 scientific publications, including invited review papers on Alzheimer's disease, and co-invented 11 patents. His technical expertise is in the areas of histopathology/neuropathology, immunohistochemistry, and image analysis. Since 1996, he was Team Leader and Principal Scientist of Target Validation Team at Johnson & Johnson Pharmaceutical Research & Development. There he discovered and validated novel targets, biomarkers, and compounds to treat cancer, inflammatory diseases, and Alzheimer's disease, and accepted numerous awards for these endeavors. Currently, he is president and histopathologist at Slidomics, LLC.

He has presented is Alzheimer's research at the following sponsored international, national and regional meetings: Society of Neuroscience; International Conference on Alzheimer's Disease and Related Disorders; The Alzheimer's Imaging Consortium; and International Neurodegeneration in Alzheimer's Disease, Parkinson's Disease & Related Disorders. In addition, he spoke at various meetings at the Annual Biological Staining Commission, The National Disease Research Institute, University of Pennsylvania, and was invited to lead the AlzForum's WebCast International discussion for the Alzheimer's Disease Forum on the evidence that neuronal cell death in AD is due to an autoimmune mechanism. He was also invited to the Challenging Views Of Alzheimer's Disease: Round II meeting to debate the inflammatory aspects of AD. In addition, he has reviewed international AD grants (Spain, Israel) and is on several scientific editorial boards.

He was one of the first to publish the presence of intracellular A¿42 in normal and AD neurons in 1999, first to hypothesize that plaques originate from neuronal lysis, first to report the presence of various plaques types in the AD brain, and first to provide morphological evidence of apoptotic neuronal

Dieses eBook können Sie uneingeschränkt auf allen Geräten der tolino Familie lesen. Zum Lesen auf sonstigen eReadern und am PC benötigen Sie eine Adobe ID.

"In addition to presenting and supporting his specific hypothesis, the author succeeds in conveying a number of important points regarding scientific research in general and the IHC methods specifically.... The methodical approach described here, including the careful attention to possible sources of artifacts, is a realistic portrayal of the hard work required both in the laboratory and at the microscope." -- Dr. Rhein Parri, Senior Lecturer in Pharmacology, School of Life and Health Sciences, Aston University, Birmingham, UK, in Biotechnicand Histochemistry

"....This book will delight the scientifically savvy reader with a guided tour of the process.... Dr. D’Andrea chronicles the process of scientific discovery in an insightful way that takes the reader on a journey... If you wanted a window into Alzheimer’s brain, here it is..... As a neuroscientist in the field, I found this book to be incredibly informative to the way I think about Alzheimer’s pathogenesis." - Holly Brothers, Postdoctoral Fellow, The Ohio State University, Columbus, OH, USA on Amazon

"Bursting Neurons and Fading Memories by Dr. Michael D’Andrea is a good book to read for those interested in Alzheimer’s disease (AD), its past research failures and its future promises....The book provides valuable and specific staining techniques, some of which Dr. D’Andrea has devised through trial and error, that remind me of Ramὁn y Cajal’s early trials with improving silver nitrate stains at the turn of the 20th century, to gather details about the neuron’s structure and to discover some novel facts about how it dies in the damaged nervous system. I highly recommend this book." - Jack de la Torre, MD, PhD, Professor of Neuropsychiatry (Adjunct), Department of Psychology, University of Texas at Austin, Austin, TX, USA