Caries Vaccine And The Ways To Modfiy Streptococcus Mutans (PDF)

Document from the year 2019 in the subject Medicine - Dentistry, , language: English, abstract: The development of vaccines for tooth decay has been under investigation for more than 30 years. Caries vaccines are said to be in animal testing since 1972, but difficulty in developing it and lack of economic interests are the reasons why these vaccines are not available commercially as of 2018. Streptococcus mutans has been identified as the agent to cause dental caries. This book attempts to search for ways that can intercept or modify this agent immunologically.

Resolving this, there are various aspects to be thought upon, like the pathways through which the Streptococcus mutans enters and accumulates in dental biofilm. Bacterial components which cause virulence response and how the immune pathways matured in a young child with caries are questions answered in this book. A thorough research is registered regarding modern vaccine design and its delivery, passive administration of antibodies against Streptococcus mutans virulence antigens, and degree of protection in preclinical studies and investigation. This book explains the caries protective activity of immunization with dental caries vaccine and the proof awaits the clinical trials.