Cancer Clinical Trials (PDF)
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This book provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Top researchers in academia, government, and the industry present many examples drawn from real trials. The book covers state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes. It also explains the importance of the selection of endpoints, use of historical data, multiplicity, analysis of safety data, discovery and validation of predictive signatures, dose-finding, sample size, and non-inferiority designs.
Xiaofei Wang, Ph.D., is an associate professor of biostatistics and bioinformatics at the Duke University School of Medicine, a member of Duke Cancer Institute (DCI), and the director of statistics for the Alliance Statistics and Data Center (Alliance SDC). He has been involved in the design and analysis of cancer clinical trials and translational studies and served on special emphasis panels for NIH and FDA grants. His methodology research focuses on the development of novel designs and methods for biomarker-integrated clinical studies and methods for analyzing patient data from multiple sources. He obtained his Ph.D. in biostatistics from the University of North Carolina at Chapel Hill.
Herbert Pang, Ph.D., is an assistant professor in the School of Public Health, Li Ka Shing Faculty of Medicine (LKSFM) at the University of Hong Kong. Dr. Pang also holds an adjunct faculty position in the Department of Biostatistics and Bioinformatics at Duke University. He has been
- 2016, 474 Seiten, Englisch
- Herausgegeben: Stephen L. George, Xiaofei Wang, Herbert Pang
- Verlag: Taylor & Francis
- ISBN-10: 1498706908
- ISBN-13: 9781498706902
- Erscheinungsdatum: 19.08.2016
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- Größe: 35 MB
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