Chiral Separation Methods for Pharmaceutical and Biotechnological Products (PDF)
(Sprache: Englisch)
Discusses chiral separations and offers guidance for selecting
the optimum method for desired results
Chiral separations represent the most intriguing and, by some
measures, most difficultseparations of chemical compounds. This
book provides...
the optimum method for desired results
Chiral separations represent the most intriguing and, by some
measures, most difficultseparations of chemical compounds. This
book provides...
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Discusses chiral separations and offers guidance for selecting
the optimum method for desired results
Chiral separations represent the most intriguing and, by some
measures, most difficultseparations of chemical compounds. This
book provides researchers and students an under-standing of chiral
separations and offers a convenient route to selecting the best
separation method, saving considerable time and cost in product
development.
Considering chiral separations in the biotechnological and
pharmaceutical industries, as well as for food applications, Dr.
Ahuja provides insights into a broad range of topics. Opening with
a broad overview of chiral separations, regulatory considerations
in drug product development, and basic issues in method
development, the book:
* Covers a variety of modern methods such as gas chromatography,
high performance liquid chromatography, supercritical fluid
chromatography, and capillary electrophoresis
* Deals with the impact of chirality on the biological activity of
small and large molecules
* Provides detailed information on useful chiral stationary phases
(CSPs) for HPLC
* Includes handy information on selection of an appropriate CSP,
including mechanistic studies
* Offers strategies for fast method development with HPLC, SFC,
and CE
* Discusses preparatory methods utilized in the pharmaceutical
industry
With in-depth discussions of the current state of the field as
well as suggestions to assist future developments, Chiral
Separation Methods for Pharmaceutical and Biotechnological
Products is an essential text for laboratory investigators,
managers, and regulators who are involved in chiral separations in
the pharmaceutical industry, as well as students preparing for
careers in these fields.
the optimum method for desired results
Chiral separations represent the most intriguing and, by some
measures, most difficultseparations of chemical compounds. This
book provides researchers and students an under-standing of chiral
separations and offers a convenient route to selecting the best
separation method, saving considerable time and cost in product
development.
Considering chiral separations in the biotechnological and
pharmaceutical industries, as well as for food applications, Dr.
Ahuja provides insights into a broad range of topics. Opening with
a broad overview of chiral separations, regulatory considerations
in drug product development, and basic issues in method
development, the book:
* Covers a variety of modern methods such as gas chromatography,
high performance liquid chromatography, supercritical fluid
chromatography, and capillary electrophoresis
* Deals with the impact of chirality on the biological activity of
small and large molecules
* Provides detailed information on useful chiral stationary phases
(CSPs) for HPLC
* Includes handy information on selection of an appropriate CSP,
including mechanistic studies
* Offers strategies for fast method development with HPLC, SFC,
and CE
* Discusses preparatory methods utilized in the pharmaceutical
industry
With in-depth discussions of the current state of the field as
well as suggestions to assist future developments, Chiral
Separation Methods for Pharmaceutical and Biotechnological
Products is an essential text for laboratory investigators,
managers, and regulators who are involved in chiral separations in
the pharmaceutical industry, as well as students preparing for
careers in these fields.
Inhaltsverzeichnis zu „Chiral Separation Methods for Pharmaceutical and Biotechnological Products (PDF)“
Contributors. Preface. 1 Overview of Chiral Separations (Satinder Ahuja). 2 Regulatory & Development Considerations of Chiral Compounds (Robert L. Zeid). 3 Basic Considerations in Method Development for Chiral Compounds (Satinder Ahuja). 4 Separations of Chiral Compounds on Polysaccharide Columns (Clinton W. Amoss and Norbert M. Maier). 5 Chiral Separations by Various Techniques (Jian G. Ning). 6 Chiral Discrimination Study for Polysaccharide Based Chiral Stationary Phase (Yun K. Ye). 7 Comparison of Chiral Chromatographic Columns for Pharmaceuticals (Gregory K. Webster). 8 Chiral Separation Screens for Pharmaceutical Analysis and Purification in an Industrial Laboratory Environment (Robert DePianta, Kenneth Douville, Beverly Nickerson, and Ricardo E. Borjas). 9 The Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases (Volker Schurig). 10 Separations of Chiral Compounds by SFC (Ziqiang Wang). 11 Chiral Separations by Capillary Electrophoresis (Debby Mangelings and Yvan Vander Heyden). 12 High-Throughput Screening and Method-Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE (Hasret Ates, Debby Mangelings and Yvan Vander Heyden). 13 Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers (Christopher J. Welch, Derek H. Henderson, William R. Leonard, Mirlinda Biba, Mike Zacuto, Fred Fleitz, Amude Kassim, Cheng-yi Chen, and Peter Sajonz). 14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology (Gregory K. Webster and William J. Buttner). 15 Chirality of Biomolecules and Biotechnology Products (Satinder Ahuja). Index.
Autoren-Porträt
SATINDER (SUT) AHUJA is a recognized expert in the field of chromatography and separations who has published numerous papers and more than a dozen books, including three on chiral separations. As president of Ahuja Consulting, he has advised major pharmaceutical companies in the United States, Europe, and India. He has also taught short courses for ACS and AAPS on chiral separations by chromatography. Recently, Dr. Ahuja chaired a symposium on Chiral Separations at the American Chemical Society meeting in Boston.
Bibliographische Angaben
- 2010, 1. Auflage, 400 Seiten, Englisch
- Herausgegeben: Satinder Ahuja
- Verlag: John Wiley & Sons
- ISBN-10: 047060865X
- ISBN-13: 9780470608654
- Erscheinungsdatum: 26.10.2010
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