Cholesterol Regulation of Ion Channels and Receptors (ePub)
(Sprache: Englisch)
Examines new research on the role of cholesterol in
regulating ion channels and receptors and its effect on
health
Drawing together and analyzing all the latest research findings,
this book explores the role of cholesterol in the regulation of...
regulating ion channels and receptors and its effect on
health
Drawing together and analyzing all the latest research findings,
this book explores the role of cholesterol in the regulation of...
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Examines new research on the role of cholesterol in
regulating ion channels and receptors and its effect on
health
Drawing together and analyzing all the latest research findings,
this book explores the role of cholesterol in the regulation of ion
channels and receptors, including its pathological effects. It is
the first book to comprehensively describe the complex mechanisms
by which cholesterol regulates two major classes of membrane
proteins. Moreover, it sheds new light on how cholesterol affects
essential cellular functions such as the contraction of the heart,
propagation of nerve impulses, and regulation of blood pressure and
kidney function.
Written and edited by leading pioneers in the field,
Cholesterol Regulation of Ion Channels and Receptors is
divided into three parts:
* Part I, Cholesterol Regulation of Membrane Properties,
introduces the heterogeneity of cholesterol distribution in
biological membranes and the physical and biological implications
of the formation of cholesterol-rich membrane domains.
* Part II, Cholesterol Regulation of Ion Channels,
examines the mechanisms underlying cholesterol sensitivities of ion
channels, including the regulation of ion channels by cholesterol
as a boundary lipid.
* Part III, Cholesterol Regulation of Receptors, explores
the latest discoveries concerning how cholesterol regulates
distinct types of receptors, including G-protein coupled receptors,
LDL and scavenger receptors, and innate immune system
receptors.
Increased levels of cholesterol represent a major health risk.
Understanding cholesterol regulation of ion channels and receptors
is essential for facilitating the development of new therapeutic
strategies to alleviate the impact of pathological cholesterol
conditions. With this book as their guide, readers have access to
the most current knowledge in the field.
regulating ion channels and receptors and its effect on
health
Drawing together and analyzing all the latest research findings,
this book explores the role of cholesterol in the regulation of ion
channels and receptors, including its pathological effects. It is
the first book to comprehensively describe the complex mechanisms
by which cholesterol regulates two major classes of membrane
proteins. Moreover, it sheds new light on how cholesterol affects
essential cellular functions such as the contraction of the heart,
propagation of nerve impulses, and regulation of blood pressure and
kidney function.
Written and edited by leading pioneers in the field,
Cholesterol Regulation of Ion Channels and Receptors is
divided into three parts:
* Part I, Cholesterol Regulation of Membrane Properties,
introduces the heterogeneity of cholesterol distribution in
biological membranes and the physical and biological implications
of the formation of cholesterol-rich membrane domains.
* Part II, Cholesterol Regulation of Ion Channels,
examines the mechanisms underlying cholesterol sensitivities of ion
channels, including the regulation of ion channels by cholesterol
as a boundary lipid.
* Part III, Cholesterol Regulation of Receptors, explores
the latest discoveries concerning how cholesterol regulates
distinct types of receptors, including G-protein coupled receptors,
LDL and scavenger receptors, and innate immune system
receptors.
Increased levels of cholesterol represent a major health risk.
Understanding cholesterol regulation of ion channels and receptors
is essential for facilitating the development of new therapeutic
strategies to alleviate the impact of pathological cholesterol
conditions. With this book as their guide, readers have access to
the most current knowledge in the field.
Inhaltsverzeichnis zu „Cholesterol Regulation of Ion Channels and Receptors (ePub)“
FOREWORD vii PREFACE ix CONTRIBUTORS xi I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 1 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES 3 Daniel Wu stner, Lukasz Michael Solanko, and Frederik W. Lund 2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES--AN ENERGETIC PERSPECTIVE 27 Jens A. Lundbæk and Olaf S. Andersen II CHOLESTEROL REGULATION OF ION CHANNELS 45 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS 47 Avia Rosenhouse-Dantsker and Irena Levitan 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS 69 Hwei L. Ong and Indu S. Ambudkar 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91 Elise Balse, Ste phane Hatem, and Stanley Nattel 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS 109 Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM 135 Nu ria Comes and Antonio Felipe 8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OF CAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION 161 Caroline Dart III CHOLESTEROL REGULATION OF RECEPTORS 181 9 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BY CHOLESTEROL AS A BOUNDARY LIPID 183 Francisco J. Barrantes 10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BY CHOLESTEROL 205 Gerald Gimpl and Katja Gehrig-Burger 11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITH G-PROTEIN-COUPLED RECEPTORS 231 Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov 12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION 255 Sandeep Shrivastava and Amitabha Chattopadhyay 13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLR RECEPTORS 273 Ruxana T. Sadikot INDEX 281
Autoren-Porträt von Irena Levitan, Francisco Barrantes
IRENA LEVITAN, PhD, is Associate Professor of Medicine atthe University of Illinois College of Medicine at Chicago. Her
research interests focus on the impact of dyslipidemia on K+
channels and endothelial biomechanics.
FRANCISCO J. BARRANTES is the former head of the National
Research Council (CONICET) - Bahia Blanca and UNESCO Chair of
Biophysics and Molecular Neurobiology. Currently, he is Director of
the Laboratory of Molecular Neurobiology and Professor at the
Faculty of Medical Sciences, Pontifical Catholic University of
Argentina. His current research interests focus on the
understanding of nicotinic acetylcholine receptor-membrane
cross-talk.
Bibliographische Angaben
- Autoren: Irena Levitan , Francisco Barrantes
- 2012, 1. Auflage, 302 Seiten, Englisch
- Verlag: John Wiley & Sons
- ISBN-10: 1118342305
- ISBN-13: 9781118342305
- Erscheinungsdatum: 12.06.2012
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
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- Dateiformat: ePub
- Größe: 14 MB
- Mit Kopierschutz
Sprache:
Englisch
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