Industrial Biotechnology (PDF)

Preface THE SCOPE AND IMPACT OF INDUSTRIAL BIOTECHNOLOGY HISTORY OF INDUSTRIAL BIOTECHNOLOGY Early History The Penicillin Story The Coming of the Cephalosporins The Waksman Era Strain Improvement Semi-Synthetic Antibiotics to Combat Resistant Microbes The Primary Metabolites The Shift from Antibiotics to Pharmacological Agents The Biopharmaceutical Revolution Recombinant Hosts Enzymes Bioconversions Vaccines Systems Microbiology INDUSTRIAL SYSTEMS BIOLOGY Introduction Industrial Biotechnology Market Drivers for Industrial Biotechnology Industrial Systems Biology Metabolic Models Reconstructed Metabolic Network Models Industrial Systems Biology Case Studies Conclusion and Future Perspectives FERMENTATION TECHNOLOGY Introduction Types of Fermentations Fermentation Process Fermentation Medium Design sterilization of Air and Fermentation Medium Environmental Factors Fermentation Kinetics Fermentation Equipment Recovery of Fermentation Products Concluding Remarks DIRECTED EVOLUTION OF INDUSTRIAL BIOCATALYSTS Introduction Strategies for Protein Design Assay Systems Examples Conclusions THE INDUSTRIAL PRODUCTION OF ENZYMES Introduction Enzyme Production Enzyme Improvement Large-Scale Enzyme Applications Conclusions APPLIED BIOCATALYSIS: AN OVERVIEW Introduction The Design of the Bioconversion System Bioreactors Rationalizing and Speeding Up the Development and Characterization of a Bioconversion Process Concluding Remarks NANOBIOTECHNOLOGY Setting the Stage Industrial Perspective Nanotechnology in Biology and Biochemistry Biomimicry Materials and Products Processes and Devices Outlook DOWNSTREAM PROCESSING IN INDUSTRIAL BIOTECHNOLOGY Introduction Separations in Industrial Biotechnology Examples of Downstream Processing of Different Product Groups INDUSTRIAL BIOTECHNOLOGY IN THE CHEMICAL AND PHARMACEUTICAL INDUSTRIES Introduction Biocatalytic Processes: Scientific and Technological Perspectives Biocatalytic Processes: Business and Commercial Perspective Safety, Health, and

Professor Wim Soetaert is a Professor of Biotechnology at the University of Ghent, Belgium. After being awarded his PhD in 1991, he started his career in industry as research director of large agro-industrial companies in Germany and France. He then moved to Ghent University in 2003 to become full professor at the Center of Expertise InBio.be. He is vice-chairman of the biocatalysis section within the European Federation of Biotechnology (ESAB). Prof. Soetaert is the founder and chairman of Ghent Bio-Energy Valley and the bio Base Europe Pilot Plant, an open innovation pilot plant for biobased products and processes.

Professor Erick J. Vandamme is Emeritus Professor at the Laboratory of Industrial Microbiology and Biocatalysis, Ghent University, Belgium, where he received his MSc, PhD and DSc in molecular biology, fermentation science and industrial biotechnology, respectively. He held postdoctoral positions at Oxford University, UK, MIT, Cambridge, USA, and at the University of London, UK. Professor Vandamme has edited or c-edited 12 reference books, written over 400 papers, holds several patents, and serves on the editorial boards of a number of journals. He has been awarded three honorary doctorates, and is the recipient of national and international scientific awards. He is an Elected Fellow of the American Academy of Microbiology and of the Society for Industrial Microbiology, has served on the boards of several European microbiological societies and is a member of the Royal Flemish Academy of Belgium for Science and the Arts.

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