Public Health Genomics / Jossey-Bass Public Health/Health Services Text (PDF)

Tables and Figures. Foreword. Preface. The Authors. Introduction. PART ONE: SCIENTIFIC AND SOCIAL PERSPECTIVES ON GENOMICS. CHAPTER ONE: PAST, PRESENT, AND FUTURE OF PUBLIC HEALTH GENOMICS. History of Human Genetics. History of Public Health Genetics. Impact of Genetics on Primary, Secondary, and Tertiary Prevention. Phenotypic versus Genotypic Prevention. Genomics Today. Genomics Tomorrow. CHAPTER TWO: GENOMICS AND GOVERNMENT. The NIH and the NHGRI. The NOPHG. The SACGHS. State Government Programs. Genomics and Bioterrorism Preparedness. CHAPTER THREE: BASIC MOLECULAR GENETICS. Hereditary Material. DNA Replication. Transcription and Translation. Gene Expression. Mutations and Polymorphisms. CHAPTER FOUR: MUTATIONS, POPULATION GENETICS, AND ETHNICITY. Somatic versus Germline Mutations. Types of Mutations. Causes of Mutations. Population Genetics. Race, Ethnicity, and Genomics. CHAPTER FIVE: INHERITANCE PATTERNS AND FAMILY HISTORY. Gregor Mendel and His Pea Plants. Autosomes and Sex Chromosomes. Drawing a Pedigree. Non-Mendelian Inheritance Patterns. Inheritance Patterns, Family History, and Public Health. CHAPTER SIX: GENETIC EPIDEMIOLOGY AND GENE-ENVIRONMENT INTERACTIONS. Review of Basic Concepts. Polygenic and Multifactorial Traits. Determining the Risk of Multifactorial Disorders. Determining Genetic versus Environmental Effects. Determining Patterns of Inheritance and Localizing Genes. Gene-Environment Interactions and Molecular Epidemiology. CHAPTER SEVEN: GENETIC INFORMATION, ETHICS, AND THE LAW. Examples of Genetic Discrimination and Breach of Privacy. Evolution of Privacy and Antidiscrimination Laws. Genetics Research and Concern for Privacy. Clinical Genetic Testing and the Duty to Inform. PART TWO: GENOMICS IN MATERNAL, CHILD, AND ADULT HEALTH. CHAPTER EIGHT: TOXICOLOGY, TERATOLOGY, AND PRENATAL DIAGNOSIS. Birth Defects and Embryology. Chromosomes. Prenatal Diagnosis. Preimplantation Genetic Diagnosis. CHAPTER NINE: PRECONCEPTIONAL GENETIC SCREENING AND

Claudia N. Mikail, MD, MPH, is a clinical assistant professor at the University of Massachusetts at Amherst, School of Public Health and Health Sciences and a clinical instructor at the Keck School of Medicine.

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