Nuclear-Cytoplasmic Transport / Nucleic Acids and Molecular Biology Bd.33 (PDF)
(Sprache: Englisch)
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In...
sofort als Download lieferbar
Printausgabe 171.19 €
eBook (pdf) -6%
160.49 €
80 DeutschlandCard Punkte sammeln
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „Nuclear-Cytoplasmic Transport / Nucleic Acids and Molecular Biology Bd.33 (PDF)“
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Autoren-Porträt
Weidong Yang, Ph.D. Dr. Yang is interested in exploring the molecular transport mechanisms in cells by using single-molecule tracking, super-resolution microscopy imaging and nanotechnology. His research laboratory is highly motivated to develop innovative research tools to meet the needs of solving challenging biological and biomedical problems, as they have done in the past and will be doing in the future. Currently, by developing and employing high-speed super-resolution microscopy techniques, Dr. Yang and his research team aim to solve two critical transport mechanisms involving three sub-cellular organelles in eukaryotic cells: nucleus, cytoplasm and primary cilium. Macromolecular trafficking among these compartments is suggested to be gated by two unique machineries. One is the nuclear pore complex (NPC) embedded in the nuclear envelope that mediates the bidirectional trafficking of proteins and RNAs between the cytoplasm and the nucleus; the other is the transition zone (TZ) located at the base of cilium that regulates the entry of membrane and cytosolic proteins into the cilium. Due to the challenges in elucidating kinetics and real-time transport routes for macromolecules through the sub-micrometer NPC or TZ in live cells, however, the fundamental gating mechanisms in either of these two machineries, remain obscure. Moreover, these transport mechanisms are not only the fundamental unanswered questions in cell biology, but also are closely associated with human diseases. For example, dysfunction of the nuclear transport through the NPC are linked to numerous human diseases including leukemias, cancers, and primary biliary cirrhosis. Also, defects in ciliary structure and/or function causes a variety of diseases (called ciliopathies) such as cystic kidney disease, nephronophthisis (NPHP), and retinitis pigmentosa. Thus, the fundamental knowledge of understanding the gating mechanisms in these transport systems is urgently needed to further develop
... mehr
therapeutics for the human diseases. In the Yang lab, they aim at employing and further developing high-speed super-resolution fluorescence microscopy techniques to unravel these fundamental transport mechanisms.
... weniger
Bibliographische Angaben
- 2018, 1st ed. 2018, 274 Seiten, Englisch
- Herausgegeben: Weidong Yang
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319773097
- ISBN-13: 9783319773094
- Erscheinungsdatum: 27.07.2018
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Größe: 7.63 MB
- Ohne Kopierschutz
- Vorlesefunktion
Sprache:
Englisch
Kommentar zu "Nuclear-Cytoplasmic Transport / Nucleic Acids and Molecular Biology Bd.33"
0 Gebrauchte Artikel zu „Nuclear-Cytoplasmic Transport / Nucleic Acids and Molecular Biology Bd.33“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Nuclear-Cytoplasmic Transport / Nucleic Acids and Molecular Biology Bd.33".
Kommentar verfassen