MicroRNA Detection and Pathological Functions / SpringerBriefs in Molecular Science (PDF)
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This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions.
This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research.
Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China.Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.
Dr. Haifeng Dong received his B.S. and M.S. degrees from Three Gorge University in 2005 and Chongqing University in 2008, respectively. Under the supervision of Professor Huangxian Ju, he received his Ph.D. degree from Nanjing University in 2011. He joined the group of Professor Xueji Zhang at the University of Science & Technology5). These papers have been
Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China. He is also an Adjunct Professor at Nankai University and Tsinghua University. Dr. Tian received his Master Degree in Medicine from Chinese PLA Postgraduate Medical School and Ph.D. from the Academy of Military Medical Sciences. He had been trained as a Postdoctoral Fellow for 2 years at The Queen Elizabeth Hospital, Australia. Dr. Tian's research has been focused on the specific serum proteomic profiles and genetic signatures of different diseases, especially on cancer. He also studies the antioxidants in herbal medicine and free radical biology. Dr. Tian has received more than 20 grants and published more than 300 scientific papers in peer-reviewed journals. He is on the editorial boards of several journals and serves as the Chairman of the Clinical Biochemistry and Applied Molecular Biology Association, CSBMB.
- Autoren: Xueji Zhang , Haifeng Dong , Yaping Tian
- 2015, 2015, 101 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3662472937
- ISBN-13: 9783662472934
- Erscheinungsdatum: 26.05.2015
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- Größe: 4 MB
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