Sustainable Catalysis (PDF)

Opens the door to the sustainable production of
pharmaceuticals and fine chemicals

Driven by both public demand and government regulations,
pharmaceutical and fine chemical manufacturers are increasingly
seeking to replace stoichiometric reagents used in synthetic
transformations with catalytic routes in order to develop greener,
safer, and more cost-effective chemical processes. This book
supports the discovery, development, and implementation of new
catalytic methodologies on a process scale, opening the door to the
sustainable production of pharmaceuticals and fine chemicals.

Pairing contributions from leading academic and industrial
researchers, Sustainable Catalysis focuses on key areas that
are particularly important for the fine chemical and pharmaceutical
industries, including chemo-, bio-, and organo-catalytic approaches
to C-H, C-N, and C-C bond-forming reactions.
Chapters include academic overviews of current innovations and
industrial case studies at the process scale, providing new
insights into green catalytic methodologies from proof-of-concept
to their applications in the synthesis of target organic
molecules.

Sustainable Catalysis provides the foundation needed to
develop sustainable green synthetic procedures, with coverage of
such emerging topics as:

* Catalytic reduction of amides avoiding LiAlH4 or B2H6

* Synthesis of chiral amines using transaminases

* Industrial applications of boric acid and boronic acid
catalyzed direct amidation reactions

* C-H activation of heteroaromatics

* Organocatalysis for asymmetric synthesis

Offering a balanced perspective on current limitations,
challenges, and solutions, Sustainable Catalysis is
recommended for synthetic organic chemists seeking to develop new
methodologies and for industrial chemists dedicated to large-scale
process development.