Telomerases (PDF)
Chemistry, Biology, and Clinical Applications
(Sprache: Englisch)
This book is a comprehensive and up-to-date review and
evaluation of the contemporary status of telomerase research.
Chapters in this volume cover the basic structure, mechanisms, and
diversity of the essential and regulatory subunits of
telomerase....
evaluation of the contemporary status of telomerase research.
Chapters in this volume cover the basic structure, mechanisms, and
diversity of the essential and regulatory subunits of
telomerase....
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This book is a comprehensive and up-to-date review and
evaluation of the contemporary status of telomerase research.
Chapters in this volume cover the basic structure, mechanisms, and
diversity of the essential and regulatory subunits of
telomerase. Other topics include telomerase biogenesis,
transcriptional and post-translational regulation, off-telomere
functions of telomerase and the role of telomerase in cellular
senescence, aging and cancer. Its relationship to retrotransposons,
a class of mobile genetic elements that shares similarities with
telomerase and serves as telomeres in selected organisms, are also
reviewed.
evaluation of the contemporary status of telomerase research.
Chapters in this volume cover the basic structure, mechanisms, and
diversity of the essential and regulatory subunits of
telomerase. Other topics include telomerase biogenesis,
transcriptional and post-translational regulation, off-telomere
functions of telomerase and the role of telomerase in cellular
senescence, aging and cancer. Its relationship to retrotransposons,
a class of mobile genetic elements that shares similarities with
telomerase and serves as telomeres in selected organisms, are also
reviewed.
Autoren-Porträt von Chantal Autexier, Neal Lue
NEAL F. LUE, MD, PHD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems.CHANTAL AUTEXIER, PHD, is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms.
Bibliographische Angaben
- Autoren: Chantal Autexier , Neal Lue
- 2012, 1. Auflage, 318 Seiten, Englisch
- Herausgegeben: Neal Lue, Chantal Autexier
- Verlag: John Wiley & Sons
- ISBN-10: 1118268504
- ISBN-13: 9781118268506
- Erscheinungsdatum: 15.05.2012
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