The Epigenetics of Autoimmune Diseases (PDF)

The role of epigenetic mechanisms in autoimmune disease is only now
starting to become clear. Understanding these mechanisms, their
effect on cellular function and the role of environmental factors
is vital to determining how to manage these often debilitating and
fatal diseases.

Drawing on the research of leading experts, this
book provides a valuable insight into this important new area
of autoimmunity research and a clear, up-to-date view on the
major advances in the field.

Specific coverage includes:

* How highly developed epigenetic mechanisms are involved in
several aspects of normal immune regulation, in addition to
maintaining immune tolerance to self-determinants.

* Specific epigenetic aspects of human autoimmune diseases,
including multiple sclerosis, systemic lupus erythematosus,
rheumatoid arthritis, systemic sclerosis, autoimmune diabetes,
thyroid autoimmunity, inflammatory bowel disease and autoimmune
hepatitis.

* How understanding epigenetic mechanisms can lead to therapeutic
strategies based on manipulation of this previously unexploited
facet of immune regulation.

* Discussion of the novel approaches that are being investigated
to prevent or treat autoimmune diseases.

This book is an essential resource for those actively
involved in the field. It is also of interest to basic researchers
interested in understanding the origin of autoimmunity and clinical
specialists interested in gaining in-depth understanding of the
pathogenesis of autoimmune diseases and their treatment.