Workbook for Organic Synthesis (ePub)

One approach to organic synthesis is retrosynthetic analysis. With
this approach chemists start with the structures of their target
molecules and progressively cut bonds to create simpler molecules.
Reversing this process gives a synthetic route to the target
molecule from simpler starting materials. This
"disconnection" approach to synthesis is now a
fundamental part of every organic synthesis course.

Workbook for Organic Synthesis: The Disconnection Approach,
2nd Edition

This workbook provides a comprehensive graded set of problems to
illustrate and develop the themes of each of the chapters in the
textbook Organic Synthesis: The Disconnection Approach,
2nd Edition. Each problem is followed by a fully
explained solution and discussion. The examples extend the
student's experience of the types of molecules being
synthesised by organic chemists, and the strategies they employ to
control their syntheses. By working through these examples students
will develop their skills in analysing synthetic challenges, and
build a toolkit of strategies for planning new syntheses. Examples
are drawn from pharmaceuticals, agrochemicals, natural products,
pheromones, perfumery and flavouring compounds, dyestuffs,
monomers, and intermediates used in more advanced synthetic work.
Reasons for wishing to synthesise each compound are given. Together
the workbook and textbook provide a complete course in
retrosynthetic analysis.

Organic Synthesis: The Disconnection Approach, 2nd
Edition

There are forty chapters in Organic Synthesis: The
Disconnection Approach, 2nd Edition: those on the
synthesis of given types of molecules alternate with strategy
chapters in which the methods just learnt are placed in a wider
context. The synthesis chapters cover many ways of making each type
of molecule starting with simple aromatic and aliphatic compounds
with one functional group and progressing to molecules with many
functional groups. The strategy chapters cover questions of
selectivity, protection, stereochemistry, and develop more advanced
thinking via reagents specifically designed for difficult problems.
In its second edition updated examples and techniques are included
and illustrated additional material has been added to take the
student to the level required by the sequel, Organic Synthesis:
Strategy and Control. Several chapters contain extensive new
material based on courses that the authors give to chemists in the
pharmaceutical industry.

Workbook for Organic Synthesis: The Disconnection Approach,
2nd edition, combined with the main textbook,
provides a full course in retrosynthetic analysis for chemistry and
biochemistry students, and a refresher course for organic chemists
working in industry and academia.