A Computational Investigation of Selective DNA Methylation
Site and Sequence Specificity
(Sprache: Englisch)
Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent...
Leider schon ausverkauft
versandkostenfrei
Buch
59.00 €
29 DeutschlandCard Punkte
sammeln
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „A Computational Investigation of Selective DNA Methylation “
Klappentext zu „A Computational Investigation of Selective DNA Methylation “
Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens.
Bibliographische Angaben
- Autoren: Kaushalya S. Ekanayake , Pierre R. Le Breton
- 2008, 140 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller
- ISBN-10: 3639052439
- ISBN-13: 9783639052435
Sprache:
Englisch
Kommentar zu "A Computational Investigation of Selective DNA Methylation"
0 Gebrauchte Artikel zu „A Computational Investigation of Selective DNA Methylation“
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "A Computational Investigation of Selective DNA Methylation".
Kommentar verfassen