A Total Synthesis of Leucascandrolide A
Application of the Mukaiyama aldol-Prins Reaction and Studies Towards a Stereoselective Synthesis of Tetrahydrofuran Rings
(Sprache: Englisch)
The total synthesis of Leucascandrolide A has been of interest to many chemists for the twelve years that have passed since it was first isolated. Leucascandrolide A's potent biological activity towards both yeast and cancer cell lines no doubt make it an...
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The total synthesis of Leucascandrolide A has been of interest to many chemists for the twelve years that have passed since it was first isolated. Leucascandrolide A's potent biological activity towards both yeast and cancer cell lines no doubt make it an interesting synthetic target, but synthetic chemists are most attracted by its distinct structural features including a 14-membered macrolide ring, two tri-substituted tetrahydropyran moieties, and eight stereocenters. Although the bulk of this book is dedicated to the methodology of the Mukaiyama aldol-Prins reaction and its application towards this total synthesis, there is a short chapter included at the end which details studies conducted towards a reagent-controlled, diastereoselective synthesis of 2,5-disubstituted tetrahydropyran rings.
Autoren-Porträt von Van Orden Lori Jean, Lori J. Van Orden
Van Orden Lori JeanLori Jean graduated with a BS in chemistry from the University of North Carolina-Chapel Hill in 2002 then went on to earn a Ph.D. in synthetic organic chemistry from Professor Scott Rychnovsky at The University of California, Irvine in 2007. She currently resides in San Francisco and works as a scientist in the pharmaceutical industry.
Bibliographische Angaben
- Autoren: Van Orden Lori Jean , Lori J. Van Orden
- 2008, 124 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639033213
- ISBN-13: 9783639033212
Sprache:
Englisch
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