Advances in chemical modifications in DNA and role in therapeutics
(Sprache: Englisch)
This book describes about the higher order structures of DNA mainly i-motif and G-quadruplex. Sequences with the potential to form G-quadruplexes and i-motifs are sequestered throughout genome mainly in the promoters of oncogenes and human telomeric DNA and...
Leider schon ausverkauft
versandkostenfrei
Buch
39.90 €
Produktdetails
Produktinformationen zu „Advances in chemical modifications in DNA and role in therapeutics “
Klappentext zu „Advances in chemical modifications in DNA and role in therapeutics “
This book describes about the higher order structures of DNA mainly i-motif and G-quadruplex. Sequences with the potential to form G-quadruplexes and i-motifs are sequestered throughout genome mainly in the promoters of oncogenes and human telomeric DNA and forms intramolecular tetraplex structure during the regulation of oncogene expression at the transcription level. The two important epigenetic markers in the human genome, 5-methylcytosine (mC) and 5-hydroxymethyl cytosine (hmC), are involved in gene regulation processes. This book also takes into account the various aspects of the guanine rich called G-quadruplex structure of the DNA which are formed in the promoter region of a regulator gene called c-myc. Various ligands and proteins help in stabilizing/ destabilizing the G-quadruplex structure present in the regulator gene but a mutated version of the c-myc is seen during cancer which leads to altered functions and expression of transcription protein leading to unregulated cell growth and proliferation. Thus, G-quadruplexes help in regulation of the telomerase enzyme activity and can pave a way for the anti cancer drugs which are the need of the hour.
Autoren-Porträt von Sarika Saxena, J Shankaraswamy, Shikhar Tyagi
Saxena, SarikaI am Sarika Saxena, Ph.D. in Biophysics from Delhi University, India and PDF from Konan University, Japan, now working as independent researcher on therapeutics aspects of Higher Order DNA structures using Bioinformatics, Biophysics, Structural Biology and Nanobiotechnology fields to serve society.
Bibliographische Angaben
- Autoren: Sarika Saxena , J Shankaraswamy , Shikhar Tyagi
- 2019, 68 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139458587
- ISBN-13: 9786139458585
Sprache:
Englisch
Kommentar zu "Advances in chemical modifications in DNA and role in therapeutics"
0 Gebrauchte Artikel zu „Advances in chemical modifications in DNA and role in therapeutics“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Advances in chemical modifications in DNA and role in therapeutics".
Kommentar verfassen