APC Proteins
(Sprache: Englisch)
The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein.
Leider schon ausverkauft
versandkostenfrei
Buch
141.50 €
Produktdetails
Produktinformationen zu „APC Proteins “
The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein.
Klappentext zu „APC Proteins “
The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car rying such mutations. The search for how mutations in Ape initiate and/or support progression oftumours in the intestinal tract has revealed that the Ape protein is a multifunctionalparticipant in a diverse array ofcellular functions. By collecting and assembling the chapters inthisbook, we aimed toprovide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer,heterozygosityofApeleads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions. The first recognised function of Ape was its role in Wnt signalling. o This function is one of the driving forces for how mutations in Ape ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan.
Inhaltsverzeichnis zu „APC Proteins “
1. APC and ß-Catenin DegradationJennifer Kennell and Kenneth M. Cadigan 2. Nuclear APCKristi L. Neufeld 3. APC in Cell MigrationSandrine Etienne-Manneville 4. The APC-EB1 InteractionEwan E. Morrison 5. The Role of APC in Mitosis and in Chromosome InstabilityChristine M. Caldwell and Kenneth B. Kaplan 6. Role of APC and its Binding Partners in Regulating Microtubules in MitosisShirin Bahmanyar, W. James Nelson and Angela I.M. Barth 7. The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of ApoptosisHassina Benchabane and Yashi Ahmed 8. APC and Its Modifiers in Colon CancerLawrence N. Kwong and William F. Dove 9. Tissue-Specific Tumour Suppression by APCOwen Sansom 10. Extra-Colonic Manifestations of Familial Adenomatous Polyposis ColiAlison H. Trainer
Autoren-Porträt von Inke S. Nathke
Inke Näthke is the professor of Epithelial Biology at the University of Dundee. Her research interest is to determine how specific molecular changes produce changes in cells and ultimately in whole tissues during early stages of tumourigenesis. Her focus is on colorectal cancers but the common epithelial origin of most tumours makes this work relevant to many other organs. Her work has led her to examine not only how cells move and divide but also how they know where they are, and how they work together to build a functional tissue. Professor Näthke received her training at San Jose State University, the University of California San Francisco, Stanford and Harvard Medical Schools.
Bibliographische Angaben
- Autor: Inke S. Nathke
- 2009, 148 Seiten, mit farbigen Abbildungen, Maße: 17,4 x 26,3 cm, Gebunden, Englisch
- Herausgegeben:Nathke, Inke S.; McCarthney, Brooke M.
- Herausgegeben: Inke S. Nathke, Brooke M. McCarthney
- Verlag: Landes Bioscience
- ISBN-10: 1441911448
- ISBN-13: 9781441911445
Sprache:
Englisch
Kommentar zu "APC Proteins"
0 Gebrauchte Artikel zu „APC Proteins“
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "APC Proteins".
Kommentar verfassen