Biochemical Studies on New Natural Inhibitors of Cholinesterases
(Sprache: Englisch)
Cholinesterase is a family of two related enzymes; acetylcholinesterase (AChE, acetylcholine hydrolase, EC 3.1.1.7) and butyrylcholinesterase (BChE, acylcholine acyl hydrolase, EC 3.1.1.8). Inhibition of AChE and BChE continue to be an effective strategy...
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Cholinesterase is a family of two related enzymes; acetylcholinesterase (AChE, acetylcholine hydrolase, EC 3.1.1.7) and butyrylcholinesterase (BChE, acylcholine acyl hydrolase, EC 3.1.1.8). Inhibition of AChE and BChE continue to be an effective strategy for the management of mild-to-moderate forms of Alzheimer's disease. This book describes the AChE and BChE inhibition by 81 natural products isolated from a variety of sources. Most of the newly discovered natural compounds were identified as members of new classes of cholinesterases inhibitors. The inhibition kinetics, Structure-activity relationships (SAR) and molecular docking studies on both enzymes are described. The spasmolytic properties of some of these compounds on rabbit jejunum tissues and the cytotoxicity of some selected compounds from every class of inhibitors are also discussed.
Autoren-Porträt von Asaad Khalid
Khalid, AsaadAsaad Khalid is a professor at the Substance Abuse Research Center, Jazan University, KSA. He received his Ph.D. degree in Chemistry in 2003. Prof. Asaad has established and headed the Medical Biochemistry Department at the Medicinal and Aromatic Plants Research Institute in Sudan during 2006-2013.
Bibliographische Angaben
- Autor: Asaad Khalid
- 2019, 224 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 6139928699
- ISBN-13: 9786139928699
Sprache:
Englisch
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