Biochemistry

Part I: Molecular Components of Cells 1. The Facts of Life: Chemistry Is the Logic of Biological Phenomena 2. Water: The Medium of Life3. Thermodynamics of Biological Systems4. Amino Acids and the Peptide Bond5. Proteins: Their Primary Structure and Biological Functions6. Proteins: Secondary, Tertiary, and Quaternary Structure7. Carbohydrates and the Glycoconjugates of Cell Surfaces8. Lipids 9. Membranes and Membrane Transport10. Nucleotides and Nucleic Acids11. Structure of Nucleic Acids12. Recombinant DNA, Cloning, Chimeric Genes, and Synthetic BiologyPart II: Protein Dynamics13. Enzymes Kinetics and Specificity14. Mechanisms of Enzyme Action15. Enzyme Regulation16. Molecular MotorsPart III: Metabolism and Its Regulation17. Metabolism: An Overview18. Glycolysis19. The Tricarboxylic Acid Cycle20. Electron Transport and Oxidative Phosphorylation21. Photosynthesis22. Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway23. Fatty Acid Catabolism24. Lipid Biosynthesis25. Nitrogen Acquisition and Amino Acid Metabolism26. Synthesis and Degradation of Nucleotides27. Metabolic Integration and Organ SpecializationPart IV: Information Transfer28. DNA Metabolism: Replication, Recombination, and Repair29. T ranscription and the Regulation of Gene Expression30. Protein Synthesis31. Completing the Protein Life Cycle: Folding, Processing, and Degradation32. The Reception and Transmission of Extracellular InformationAbbreviated Answers to ProblemsIndex

Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France. Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research