Biodegradable in Situ Microparticles for Sustained Protein Delivery
Stability of a Model Protein during Incorporation and Release from Biodegradable in Situ Forming Drug Delivery Systems
(Sprache: Englisch)
The objective of this work was to evaluate the suitability of in situ forming biodegradable microparticles for the controlled delivery of proteins. Particular goals were: a) to evaluate the flexibility of the release patterns of in situ implant and in situ...
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The objective of this work was to evaluate the suitability of in situ forming biodegradable microparticles for the controlled delivery of proteins. Particular goals were: a) to evaluate the flexibility of the release patterns of in situ implant and in situ microparticle formulations using hen egg white lysozyme as model protein; b) to characterize, if and how the integrity of the model protein is affected by formulation ingredients, the manufacturing process, storage of the ISM and the release from the formulations; c) to optimize protein delivery from in situ forming implant and microparticle systems, with regard to shape and completeness of the release; d) to find / validate reliable methods allowing to extract and thus to characterize the model protein in biodegradable in situ formulations.
Autoren-Porträt von Martin Körber
Körber MartinBornApril 27th, 1976 in Berlin, Germany; 1996-2001 Pharmacy studies at the FU Berlin; 2002-2007 Dissertation in pharmaceutical technology at FU Berlin (Grade: Summa cum laude); 2001-present Work on analytical and formulation R&D projects with global pharma companies
Bibliographische Angaben
- Autor: Martin Körber
- 332 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3639076591
- ISBN-13: 9783639076592
Sprache:
Englisch
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