Bioinorganic Medicinal Chemistry

MEDICINAL INORGANIC CHEMISTRY: STATE OF THE ART, NEW TRENDS, AND A VISION OF THE FUTURE
Introduction
Antimicrobial Agents
Antiviral Agents
Systemic and Metabolic Diseases Including Inflammation
Metal Chelating Agents
Antiarthritic Drugs and Inflammation
Bipolar Disorder
Anticancer Agents
Small Molecule Delivery and Control
Diagnostic Agents
Veterinary Medicinal Inorganic Chemistry
Conclusions and Vision
 
TARGETING STRATEGIES FOR METAL-BASED THERAPEUTICS
Introduction
Physiological Targeting
Molecular Targeting
Immunological Targeting
Concluding Remarks
 
CURRENT STATUS AND MECHANISM OF ACTION OF PLATINUM-BASED ANTICANCER DRUGS
Introduction
Mechanism of Action of Cisplatin
Limitations of Current Platinum-Based Compounds: New Strategies
Novel Concepts in the Development of Platinum Antitumor Drugs
Concluding Remarks
 
NEW TRENDS AND FUTURE DEVELOPMENTS OF PLATINUM-BASED ANTITUMOR DRUGS
Introduction
Mechanisms of Action and Resistance
Monofunctional Platinum(II) Complexes
Trans-Platinum(II) Complexes
Multinuclear Platinum(II) C omplexes
Platinum(IV) Complexes
Delivery of Platinum Drugs
Concluding Remarks and Future Perspectives
 
RUTHENIUM AND OTHER NON-PLATINUM ANTICANCER COMPOUNDS
Introduction
Ruthenium Anticancer Compounds
From Gallium Nitrate to Oral Gallium Complexes
Titanium Anticancer Compounds
Ferrocene-Derived Anticancer Agents
The Main Group Organometallics Spirogermanium and Germanium-132
Arsenic in Cancer Chemotherapy
Overcoming the Resistance of Tumors to Anticancer Agents by Rare Earth Element Compounds
Conclusions
 
THE CHALLENGE OF ESTABLISHING RELIABLE SCREENING TESTS FOR SELECTING ANTICANCER METAL COMPOUNDS
Introduction
Tumor Cell Growth Inhibition and Cell Death Screening Assays
Metal-Based Anticancer Compounds and Gene Expression Microarray Technologies
Metal-Based Anticancer Compounds and the Proteomic Approach
Concluding Remarks
 
GOLD-BASED THERAPEUTIC AGENTS: A

Enzo Alessio was born in 1958, studied chemistry at the University of Trieste (Italy) and received his Ph D from the University of Ferrara (Italy) in 1989. After a NATO-CNR postdoctoral fellowship with Luigi G. Marzilli at Emory University (Atlanta), he became first Research Associate and then Associate Professor of Inorganic Chemistry at the University of Trieste, where he is now director of the Ph D School in Chemistry. He is co-author of more than 150 publications and 10 patents in the fields of coordination chemistry, metal-based anticancer drugs, and metal-driven construction of supramolecular architectures, in particular multi-chromophore assemblies for photophysical applications.

"This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic." (O Six Media, 15 February 2011)

"Expert readers looking for an up-to-date overview of recent developments in their field of research as well as doctoral students with a certain background knowledge in bioinorganic chemistry entering this highly interdisciplinary and quickly advancing field are the main audience for this well-edited book and will benefit from the concise treatment as well as the many references to highly topical primary publications."Angewandte Chemie, November 2011 doi:10.1002/anie.201104828