Biology of Brain Tumour
Proceedings of the Second International Symposium on Biology of Brain Tumour (London, October 24-26, 1984)
(Sprache: Englisch)
Proceedings of the Second International Symposium on Biology of Brain Tumour, London, October 24-26, 1984
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Proceedings of the Second International Symposium on Biology of Brain Tumour, London, October 24-26, 1984
Klappentext zu „Biology of Brain Tumour “
This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts.
Inhaltsverzeichnis zu „Biology of Brain Tumour “
Section I. Molecular Neurooncology1. Molecular Biology of Cancer
2. Two-Dimensional Gel Electrophoretic Protein Patterns in High-Grade Human Astrocytomas
3. Biochemical Studies of Primary Cultures from Human Astrocytomas: Observations on Cell Growth and Regulation of Glutamine Synthetase
4. Dibutyryl Adenosine 3?:5?-Cyclic Monophosphate (db-cAMP) Induced Growth Inhibition and Morphologic Changes in Human Medulloblastoma Cell line TE671
5. Phenotypic Modification of Human Glioma
6. Chromosomes and Chromosomal Progression of Malignant Human Gliomas: Theoretical and Practical Implications
7. Differential Expression of Neuron Specific Enolase and Creatine Phosphokinase-BB by Human Medulloblastoma and Glioma Tumors and Neuroectodermal Cell Lines
8. Neovascularisation of Intracranial Tumours
9. Red Blood Cell Polyamines in Malignant Glioma Patients. Spermidine and Spermine Blood Levels and Tumour Evolution
Section II. Modern Neuropathology
10. Pathological Classification of Tumours of the Central Nervous System
11. Modem Neuropathological Investigative Techniques of Brain Tumours
12. Adenylate Cyclase Activity and Cyclic AMP Content in Human Central Nervous System Tumors and in Cerebrospinal Fluid of Patients Bearing Brain Tumors
13. Non-Nuclear Cytotoxic Actions of DNA Cross-Linking and/or Alkylating Agents in Glioma- Derived Cell Lines
14. Intracerebral Transplantation of D-54 MG Human Glioma Line in Immunosuppressed Rats
15. In vivo Characterization of a Human Neuroectodermal Tumor Cell Line
16. Carbonic Anhydrase C as a Marker Antigen in the Diagnosis of Choroid Plexus Papillomas and Other Tumours: An Immunoperoxidase Study
17. Transplacental ENU Tumors of the Rat: Immunohistochemical Contribution to the Recognition of Cell Types
18. Vascularization of Human Cerebral Gliomas: A Lectin-Cytochemical and Morphometric Study
19. Immunohistochemical Demonstration of HLA-DR Positive Cells in Normal and Neoplastic Brain Tissues. I. Preliminary
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20. Primary Non-Hodgkin Lymphomas of the Central Nervous System
21. Evaluation of a Transplantable Mouse Brain Tumour: A Model for the Study of Human Glioma
Section III. Correlates of Brain Tumour Imaging
22. Neuropathology and Imaging. The Ways in Which Glioma Spreads and Varies in Its Histological Aspect
23. Magnetic Resonance Imaging of Central Nervous System Tumors
24. Radioimmunolocalisation of Primary Cerebral Tumours in Humans
25. Histological Factors in the Prognosis of Malignant Astrocytomas
26. Correlation of Target Site with Histology and Cell Culture in CT-directed Stereotactic Biopsy
27. The Vasculature of Experimental Brain Tumours: Angiogenesis, Vascular Pathology and Per-meability Studies
28. An Autoradiographic Approach for Studying the Distribution of Neurotransmitter Receptor Binding Sites on Biopsy Samples of Human Gliomas
29. Drug Delivery to Brain Tumors: Physiological and Pharmacokinetic Aspects of Chemotherapy
30. Experimental Models of Rat Brain Tumors by Stereotactic Injection of C6 Glioma and HTC Hepatoma Cell Lines
31. Cerebral Infarction as a Result of Tumor Emboli
Section IV. Surgical Neurooncology
32. Technical Approaches to Identification and Stereotactic Reduction of Tumor Burden
33. A Surgical History of Maida Vale Hospital
34. Pre-Operative Stereo-Scanning for Glioma Treatment Planning
35. Stereotactic Curietherapy of Thalamic Tumours
36. Intraoperative Radiation Therapy for Glioblastoma Multiforme
37. 'Radical' Surgical Decompression of Supratentorial Gliomas. Do the Results Justify the Opera-tion?
38. Laser Microsurgery: A Review of 110 Tumors of the Brain and Spinal Cord
39. Carbon Dioxide Laser Surgery For Malignant Glioma
40. Long Term Results of Ventricular Shunts Performed Prior to Posterior Fossa Operation for Tumor
41. Radical Laser Surgery in the Treatment of Gliomas
42. Preliminary Observation on the Use of the Local Thermochemotherapy in the Treatment of Malignant Cerebral Tumors
43. Remarks on the Surgical Treatment of Bilateral Transcallosal Gliomas
Section V. The Biology of Radiotherapy
44. Radiation Damage to Brain and Cranial Soft Tissues: Outcome and Incidence Before and After Reduction in Dose
45. Radiotherapy with a Three-Fraction Per Day Regimen in a Split Course of Irradiation for Malignant High Grade Astrocytomas
46. Non-Invasive Thermochemotherapy for Advanced Brain Tumors
47. 252CF Neutron Brachytherapy for Malignant Glioma at the University of Kentucky and a Malig-nant Glioma Therapeutic Staging System
48. Permanent Radioactive Iodine Seed Implants Following Radical Resection in Recurrent Human Malignant High Grade Astrocytomas
49. Technique and Preliminary Results of Interstitial Irradiation for Recurrent Glial Tumors
50. Results of Definitive Irradiation for Optic Gliomas
Section VI. Drug Therapy
51. Current Approaches to Chemotherapy
52. Cisplatin, Arabinofuranosyl Cytosine, and Caffeine Before Radiation for Glioblastomas
53. Multimodality Therapy of Supratentorial High-Grade Gliomas
54. The Use of Experimental Models of Human Medulloblastoma in the Design of Rational Therapy
55. Phase II Study of Novantrone (Mitoxantrone Hydorchloride) in Adults with Grade III-IV Astrocytomas
56. An Experimental Study of Xenografted Human Gliomas
57. Human Central Nervous System Pharmacology of Tiazofurin
58. Primary Therapy of Medulloblastoma with Surgery, Radiation, and Methotrexate and BCNU - A Pilot Study
59. Cyclophosphamide, Adriamycin, Vincristine, and Dexamethasone in the Treatment of Bulky Central Nervous System Lymphoma
60. Effect of Intracarotid Administration of BCNU in Rats
61. Intravenous and Subarachnoid Adriamycin in Experimental Meningeal Carcinomatosis: Tissue Concentration and Therapeutic Efficacy
62. Adriamycin in the Treatment of Malignant Meningiomas
63. Heterogeneity in Response of Short-Term Glioma Cell Cultures to Cytotoxic Drugs: Correlation of In Vitro Chemosensitivity and Relapse Free Interval
64. High Dose Polichemotherapy with Autologous Bone Marrow Transplantation in Recurrent Medulloblastoma. A Pilot Study
65. Phase I Study of Intraarterial Mitomycin-C for Recurrent Intracerebral Tumors
66. In Vitro Phase II Trial with the Human Tumor Stem Cell Assay as a New Brain Tumor Model for Drug Screening: Preliminary Results
Section VII. Immunoneurobiology
67. Immunotherapy of Patients with Brain Tumors - Current Prospective
68. Effect of Interferons and an Interferon Inducer on Malignant Brain Tumors
69. Antigenic Heterogeneity of Human Glioma Tissue and Cell Lines (HGL) Defined by Monoclonal Antibodies (MAs)
70. T-Cell Mediated Cytotoxicity in Human Glioma
71. Modulation of HLA-DR Expression and Growth Inhibition on Glioma Cells: Heterogeneous Responses to Interferon
20. Primary Non-Hodgkin Lymphomas of the Central Nervous System
21. Evaluation of a Transplantable Mouse Brain Tumour: A Model for the Study of Human Glioma
Section III. Correlates of Brain Tumour Imaging
22. Neuropathology and Imaging. The Ways in Which Glioma Spreads and Varies in Its Histological Aspect
23. Magnetic Resonance Imaging of Central Nervous System Tumors
24. Radioimmunolocalisation of Primary Cerebral Tumours in Humans
25. Histological Factors in the Prognosis of Malignant Astrocytomas
26. Correlation of Target Site with Histology and Cell Culture in CT-directed Stereotactic Biopsy
27. The Vasculature of Experimental Brain Tumours: Angiogenesis, Vascular Pathology and Per-meability Studies
28. An Autoradiographic Approach for Studying the Distribution of Neurotransmitter Receptor Binding Sites on Biopsy Samples of Human Gliomas
29. Drug Delivery to Brain Tumors: Physiological and Pharmacokinetic Aspects of Chemotherapy
30. Experimental Models of Rat Brain Tumors by Stereotactic Injection of C6 Glioma and HTC Hepatoma Cell Lines
31. Cerebral Infarction as a Result of Tumor Emboli
Section IV. Surgical Neurooncology
32. Technical Approaches to Identification and Stereotactic Reduction of Tumor Burden
33. A Surgical History of Maida Vale Hospital
34. Pre-Operative Stereo-Scanning for Glioma Treatment Planning
35. Stereotactic Curietherapy of Thalamic Tumours
36. Intraoperative Radiation Therapy for Glioblastoma Multiforme
37. 'Radical' Surgical Decompression of Supratentorial Gliomas. Do the Results Justify the Opera-tion?
38. Laser Microsurgery: A Review of 110 Tumors of the Brain and Spinal Cord
39. Carbon Dioxide Laser Surgery For Malignant Glioma
40. Long Term Results of Ventricular Shunts Performed Prior to Posterior Fossa Operation for Tumor
41. Radical Laser Surgery in the Treatment of Gliomas
42. Preliminary Observation on the Use of the Local Thermochemotherapy in the Treatment of Malignant Cerebral Tumors
43. Remarks on the Surgical Treatment of Bilateral Transcallosal Gliomas
Section V. The Biology of Radiotherapy
44. Radiation Damage to Brain and Cranial Soft Tissues: Outcome and Incidence Before and After Reduction in Dose
45. Radiotherapy with a Three-Fraction Per Day Regimen in a Split Course of Irradiation for Malignant High Grade Astrocytomas
46. Non-Invasive Thermochemotherapy for Advanced Brain Tumors
47. 252CF Neutron Brachytherapy for Malignant Glioma at the University of Kentucky and a Malig-nant Glioma Therapeutic Staging System
48. Permanent Radioactive Iodine Seed Implants Following Radical Resection in Recurrent Human Malignant High Grade Astrocytomas
49. Technique and Preliminary Results of Interstitial Irradiation for Recurrent Glial Tumors
50. Results of Definitive Irradiation for Optic Gliomas
Section VI. Drug Therapy
51. Current Approaches to Chemotherapy
52. Cisplatin, Arabinofuranosyl Cytosine, and Caffeine Before Radiation for Glioblastomas
53. Multimodality Therapy of Supratentorial High-Grade Gliomas
54. The Use of Experimental Models of Human Medulloblastoma in the Design of Rational Therapy
55. Phase II Study of Novantrone (Mitoxantrone Hydorchloride) in Adults with Grade III-IV Astrocytomas
56. An Experimental Study of Xenografted Human Gliomas
57. Human Central Nervous System Pharmacology of Tiazofurin
58. Primary Therapy of Medulloblastoma with Surgery, Radiation, and Methotrexate and BCNU - A Pilot Study
59. Cyclophosphamide, Adriamycin, Vincristine, and Dexamethasone in the Treatment of Bulky Central Nervous System Lymphoma
60. Effect of Intracarotid Administration of BCNU in Rats
61. Intravenous and Subarachnoid Adriamycin in Experimental Meningeal Carcinomatosis: Tissue Concentration and Therapeutic Efficacy
62. Adriamycin in the Treatment of Malignant Meningiomas
63. Heterogeneity in Response of Short-Term Glioma Cell Cultures to Cytotoxic Drugs: Correlation of In Vitro Chemosensitivity and Relapse Free Interval
64. High Dose Polichemotherapy with Autologous Bone Marrow Transplantation in Recurrent Medulloblastoma. A Pilot Study
65. Phase I Study of Intraarterial Mitomycin-C for Recurrent Intracerebral Tumors
66. In Vitro Phase II Trial with the Human Tumor Stem Cell Assay as a New Brain Tumor Model for Drug Screening: Preliminary Results
Section VII. Immunoneurobiology
67. Immunotherapy of Patients with Brain Tumors - Current Prospective
68. Effect of Interferons and an Interferon Inducer on Malignant Brain Tumors
69. Antigenic Heterogeneity of Human Glioma Tissue and Cell Lines (HGL) Defined by Monoclonal Antibodies (MAs)
70. T-Cell Mediated Cytotoxicity in Human Glioma
71. Modulation of HLA-DR Expression and Growth Inhibition on Glioma Cells: Heterogeneous Responses to Interferon
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Bibliographische Angaben
- 2013, Softcover reprint of the original 1st ed. 1986., 515 Seiten, Maße: 27,9 cm, Kartoniert (TB), Englisch
- Herausgegeben:Walker, Michael D.; Thomas, David G..T.
- Verlag: Springer
- ISBN-10: 1461294150
- ISBN-13: 9781461294153
Sprache:
Englisch
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