Cardiovascular Genomics
Methods and Protocols
(Sprache: Englisch)
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In...
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Produktinformationen zu „Cardiovascular Genomics “
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
Klappentext zu „Cardiovascular Genomics “
As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies. In Cardiovascular Genomics: Methods and Protocols, experts in the field provide methods for cardiovascular phenotyping of rodent models in the first section of the volume and for statistical and bioinformatic integration of phenotype data with genome-wide genotype and expression data in the second section. Understanding these diverse methods will allow an individual laboratory to utilize these genomic methods independently or to better prepare for collaboration with scientists having expertise in other disciplines in order to uncover genes affecting cardiovascular disease. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary equipment, materials, and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Cutting-edge and easy-to-use, Cardiovascular Genomics: Methods and Protocols will enable researchers to identify causal genes and novel molecular targets that can lead to vital new treatments for cardiovascular disease.
Inhaltsverzeichnis zu „Cardiovascular Genomics “
1. Modes of Defining Atherosclerosis in Mouse Models: Relative Merits and Evolving StandardsAlan Daugherty, Hong Lu, Deborah A. Howatt, and Debra L. Rateri2. Evaluating Micro- and Macro-Vascular Disease, the End Stage of Atherosclerosis, in Rat ModelsJames C. Russell3. Non-Invasive Blood Pressure Measurement in MiceMinjie Feng and Keith DiPetrillo4. Direct Blood Pressure Monitoring in Laboratory Rodents via Implantable Radio TelemetryDaniel A. Huetteman and Heather Bogie5. Measuring Kidney Function in Conscious MiceDavid L. Mattson6. Ischemic Stroke in Mice and RatsAysan Durukan and Turgut Tatlisumak7. Mouse Surgical Models in Cardiovascular ResearchOleg Tarnavski8. Echocardiographic Examination in Rats and MiceJing Liu and Dean F. Rigel9. QTL Mapping in Intercross and Backcross PopulationsFei Zou10. Quantitative Trait Locus Analysis Using J/qtlRandy Smith, Keith Sheppard, Keith DiPetrillo, and Gary Churchill11. Computing Genetic Imprinting Expressed by HaplotypesYun Cheng, Arthur Berg, Song Wu, Yao Li, and Rongling Wu12. Haplotype Association Mapping in MiceShirng-Wern Tsaih and Ron Korstanje13. Candidate Gene Association AnalysisJonathan B. Singer14. Genome-Wide Association Study in HumansJ. Gustav Smith and Christopher Newton-Cheh15. Bioinformatics Analysis of Microarray DataYunyu Zhang, Joseph Szustakowski, and Martina Schinke16. eQTL Analysis in Mice and RatsBruno M. Tesson and Ritsert C. Jansen17. eQTL Analysis in HumansLude Franke and Ritsert C. Jansen18. A Systematic Strategy for the Discovery of Candidate Genes Responsible for Phenotypic VariationPaul Fisher, Harry Noyes, Stephen Kemp, Robert Stevens, and Andrew Brass
Bibliographische Angaben
- 2014, 350 Seiten, Maße: 26 cm, Kartoniert (TB), Englisch
- Herausgegeben:DiPetrillo, Keith
- Verlag: Humana Press
- ISBN-10: 1617796433
- ISBN-13: 9781617796432
Sprache:
Englisch
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