Cellular Peptidases in Immune Functions and Diseases 2
(Sprache: Englisch)
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase...
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Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Inhaltsverzeichnis zu „Cellular Peptidases in Immune Functions and Diseases 2 “
Part I: Membrane Ectopeptidases with Influence on Immune Functions. Review: - The Role of Membrane Peptidases in Immune Functions; U. Lendeckel, et al.
- Structure and Function of Aminopeptidase N; H. Sjöström, et al.
- Modulation of WNT-5a Expression by Actinonin: Linkage of APN to the WNT-Pathway? U. Lendeckel, et al.
- Enzymatic Activity is not a Precondition for the Intracellular Calcium Increase Mediated by mAbs Specific for Aminopeptidase N/CD13; A. Navarrete Santos, et al.
- Transforming Growth Factor-b Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Monocytes and Monocytic Cell Lines; A. Kehlen, et al.
- Cell-Cell Contact Between Lymphocytes and Fibroblast-like Synoviocytes Induces Lymphocytic Expression of Aminopeptidase N/CD13 and Results in Lymphocytic Activation; D. Riemann, et al.
- Natural Substrates of Dipeptidyl Peptidase IV; I. De Meester, et al.
- Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV: Point Mutations that Influence Adenosine Deaminase Binding, Antibody Binding and Enzyme Activity; M. D. Gorrell, et al.
- Development of a Tertiary-Structure Model of the C-Terminal Domain of DPP IV; W. Brandt.
- Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity: Post-Proline Peptidases; C. A. Abbott, et al.
- A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidase IV (DP IV/CD26) Activity; S. Lorey, et al.
- Potent Inhibitors of Dipeptidyl Peptidase IV and their Mechanisms of Inhibition; A. Stöckel-Maschek, et al.
- N-terminal HIV-1 TAT Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterization; C. Mrestani-Klaus, et al.
- Signal Transduction Events Induced or Affected by Inhibition of the Catalytic Activity of Dipeptidyl Peptidase IV (DP IV, CD26); T. Kähne, et al.
- Specific Inhibitors of Dipeptidyl Peptidase IV Suppress mRNA Expression of DP IV/CD26 and Cytokines; M.
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Arndt, et al.
- Dipeptidyl Peptidase IV in Inflammatory CNS Disease; A. Steinbrecher, et al.
- Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease; D. Reinhold, et al.
- Effects of Nonapeptides Derived from the N-Terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) TAT on Suppression of CD26-Dependent T Cell Growth; S. Wrenger, et al.
- DNA Synthesis in Cultured Human Keratinocytes and HaCaT Keratinocytes is Reduced by Specific Inhibition of Dipeptidyl Peptidase IV (CD26) Enzymatic Activity; R. Vetter, et al.
- Attractin: A CUB-Family Protease Involved in T Cell-Monocyte/ Macrophage Interactions; J. S. Duke-Cohan, et al.
- Analogs of Glucose-Dependent Insulinotropic Polypeptide with Increased Dipeptidyl Peptidase IV Resistance; K. Kühn-Wache, et al.
- Dipeptidyl Peptidase IV (DPP IV, CD26) in Patients with Mental Eating Disorders; M. Hildebrandt, et al.
- The Membrane-Bound Ectopeptidase CPM as a Marker of Macrophage Maturation in Vitro and in Vivo; M. Rehli, et al.
- Matrix Metalloproteinases (MMP-8, -13, and -14) Interact with the Clotting System and Degrade Fibrinogen and Factor XII (Hagemann Factor); H.arald Tschesche, et al.
- The Neprilysin Family in Health and Disease; A. J. Turner, et al.
Part II: Cellular Endopeptidases:
- New Cathepsins; Results from Knock-out-mice; Regulatory Aspects. Review: Novel Cysteine Proteases of the Papain Family; F. Bühling, et al.
- Development and Validation of Homology Models of Human Cathepsins K, S, H, and F; A. Fengler, Wolfgang Brandt.
- The Function of Propeptide Domains of Cysteine Proteinases; B. Wiederanders.
- Human Cathepsins W and F Form a New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-like Cysteine Proteases; T. Wex, et al.
- Cathepsin K Expression in Human Lung; F. Bü, et al.
- Expression of Cathepsins B and L in Human Lung Epithelial Cells is Regulated by Cytokines; A. Gerber, et al.
- Functions of Cathepsin K in Bone Resorption: Lessons from Cathepsin K Deficient Mice; P. Saftig, et al.
- Ceramide as an Activator Lipid of Cathepsin D; M. Heinrich, et al.
- Human Cathepsin X: A Novel Cysteine Protease with Unique Specificity; R. Ménard, et al.
- A Novel Proteolytic Mechanism for Termination of the Ca2+ Signalling Evoked by Proteinase-Activated Receptor-1 (PAR-1) in Rat Astrocytes; J. J. Ubl, G. Reiser.
- Natural and Synthetic Inhibitors of the Tumor-Associated Serine Protease Urokinase-Type Plasminogen Activator; V. Magdolen, et al.
- Processing of Interleukin-18 by Human Vascular Smooth Muscle Cells; E. Westphal, et al.
Part III: Peptidases and Peptidase Inhibitors in Pathogenesis of Diseases.
- Review: Peptidases and Peptidase Inhibitors in the Pathogenesis of Diseases: Disturbances in the Ubiquitin-Mediated Proteolytic System.Protease-Antiprotease Imbalance in Inflammatory Reactions. Role of Cathepsins in Tumour Progression; U. Bank, et al.
- The Role of Proteolysis in Alzheimer's Disease; N. M. Hooper, et al.
- Observing Proteases in Living Cells; K. Moin, et al.
- The Role of Cysteine Proteases in Intracellular Pancreatic Serine Protease Activation; M. M. Lerch, et al.
- Peptidases in the Asthmatic Airways; V. H.J. van der Velden, et al. Inactivation of Interleukin-6 by Neutrophil Proteases at Sites of Inflammation: Protective Effects of Soluble IL-6 Receptor Chains; U. Bank, et al.
- Antisense Inhibition of Cathepsin B in a Human Osteosarcoma Cell Line; S. Krueger, et al.
- Protease-Protease Inhibitor Balance in the Gastric Mucosa: Influence of Helicobacter Pylori Infection; M. Nilius, et al.
- The Role of Bacterial and Host Proteinases in Periodontal Disease; J. Travis, et al.
- Multifunctional Role of Proteases in Rheumatic Diseases; J. Kekow, et al.
- Evidence of Proteolytic Activation of Transforming Growth Factor &bgr; in Synovial Fluid; S. Zielinski, et al.
- Matrix Metalloproteinases and Tace Play a Role in the Pathogenesis of Endometriosis; C. Gottschalk, et al.
- Influence of Proliferation, Differentiation and Dedifferentiation Factors on the Expression of the Lysosomal Cysteine Proteinase Cathepsin L (CL) in Thyroid Cancer Cell Lines; A. Plehn, et al.
- Contributors. Index
- Dipeptidyl Peptidase IV in Inflammatory CNS Disease; A. Steinbrecher, et al.
- Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease; D. Reinhold, et al.
- Effects of Nonapeptides Derived from the N-Terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) TAT on Suppression of CD26-Dependent T Cell Growth; S. Wrenger, et al.
- DNA Synthesis in Cultured Human Keratinocytes and HaCaT Keratinocytes is Reduced by Specific Inhibition of Dipeptidyl Peptidase IV (CD26) Enzymatic Activity; R. Vetter, et al.
- Attractin: A CUB-Family Protease Involved in T Cell-Monocyte/ Macrophage Interactions; J. S. Duke-Cohan, et al.
- Analogs of Glucose-Dependent Insulinotropic Polypeptide with Increased Dipeptidyl Peptidase IV Resistance; K. Kühn-Wache, et al.
- Dipeptidyl Peptidase IV (DPP IV, CD26) in Patients with Mental Eating Disorders; M. Hildebrandt, et al.
- The Membrane-Bound Ectopeptidase CPM as a Marker of Macrophage Maturation in Vitro and in Vivo; M. Rehli, et al.
- Matrix Metalloproteinases (MMP-8, -13, and -14) Interact with the Clotting System and Degrade Fibrinogen and Factor XII (Hagemann Factor); H.arald Tschesche, et al.
- The Neprilysin Family in Health and Disease; A. J. Turner, et al.
Part II: Cellular Endopeptidases:
- New Cathepsins; Results from Knock-out-mice; Regulatory Aspects. Review: Novel Cysteine Proteases of the Papain Family; F. Bühling, et al.
- Development and Validation of Homology Models of Human Cathepsins K, S, H, and F; A. Fengler, Wolfgang Brandt.
- The Function of Propeptide Domains of Cysteine Proteinases; B. Wiederanders.
- Human Cathepsins W and F Form a New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-like Cysteine Proteases; T. Wex, et al.
- Cathepsin K Expression in Human Lung; F. Bü, et al.
- Expression of Cathepsins B and L in Human Lung Epithelial Cells is Regulated by Cytokines; A. Gerber, et al.
- Functions of Cathepsin K in Bone Resorption: Lessons from Cathepsin K Deficient Mice; P. Saftig, et al.
- Ceramide as an Activator Lipid of Cathepsin D; M. Heinrich, et al.
- Human Cathepsin X: A Novel Cysteine Protease with Unique Specificity; R. Ménard, et al.
- A Novel Proteolytic Mechanism for Termination of the Ca2+ Signalling Evoked by Proteinase-Activated Receptor-1 (PAR-1) in Rat Astrocytes; J. J. Ubl, G. Reiser.
- Natural and Synthetic Inhibitors of the Tumor-Associated Serine Protease Urokinase-Type Plasminogen Activator; V. Magdolen, et al.
- Processing of Interleukin-18 by Human Vascular Smooth Muscle Cells; E. Westphal, et al.
Part III: Peptidases and Peptidase Inhibitors in Pathogenesis of Diseases.
- Review: Peptidases and Peptidase Inhibitors in the Pathogenesis of Diseases: Disturbances in the Ubiquitin-Mediated Proteolytic System.Protease-Antiprotease Imbalance in Inflammatory Reactions. Role of Cathepsins in Tumour Progression; U. Bank, et al.
- The Role of Proteolysis in Alzheimer's Disease; N. M. Hooper, et al.
- Observing Proteases in Living Cells; K. Moin, et al.
- The Role of Cysteine Proteases in Intracellular Pancreatic Serine Protease Activation; M. M. Lerch, et al.
- Peptidases in the Asthmatic Airways; V. H.J. van der Velden, et al. Inactivation of Interleukin-6 by Neutrophil Proteases at Sites of Inflammation: Protective Effects of Soluble IL-6 Receptor Chains; U. Bank, et al.
- Antisense Inhibition of Cathepsin B in a Human Osteosarcoma Cell Line; S. Krueger, et al.
- Protease-Protease Inhibitor Balance in the Gastric Mucosa: Influence of Helicobacter Pylori Infection; M. Nilius, et al.
- The Role of Bacterial and Host Proteinases in Periodontal Disease; J. Travis, et al.
- Multifunctional Role of Proteases in Rheumatic Diseases; J. Kekow, et al.
- Evidence of Proteolytic Activation of Transforming Growth Factor &bgr; in Synovial Fluid; S. Zielinski, et al.
- Matrix Metalloproteinases and Tace Play a Role in the Pathogenesis of Endometriosis; C. Gottschalk, et al.
- Influence of Proliferation, Differentiation and Dedifferentiation Factors on the Expression of the Lysosomal Cysteine Proteinase Cathepsin L (CL) in Thyroid Cancer Cell Lines; A. Plehn, et al.
- Contributors. Index
... weniger
Bibliographische Angaben
- 2013, 2002, XV, 522 Seiten, Maße: 17,8 x 25,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Jürgen Langner, Siegfried Ansorge
- Verlag: Springer, Berlin
- ISBN-10: 1475786492
- ISBN-13: 9781475786491
Sprache:
Englisch
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