Chemical Aspects of Enzyme Biotechnology

Enzyme Mechanisms.- Effect of Metal Ions and Adenylylation State on the Energetics of the E. Coli Glutamine Synthetase Reaction.- Structure-Function Relationships in Mandelate Racemase and Muconate Lactonizing Enzyme.- An Enzyme-Targeted Herbicide-Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies.- Mechanism of Enzymatic Phosphotriesters Hydrolysis.- Protein Folding.- Proline Isomerization and Protein Folding.- Increasing Enzyme Stability.- A Study of Subunit Folding and Dimer Assembly In Vivo.- Characterization of a Transient intermediate in the Folding of Dihydrofolate Reductase.- Design and Redesign of Enzymes and Proteins.- From Biological Diversity to Structure-Function Analysis: Protein Engineering in Asparate Transcarbamoylase.- Catalytic Antibodies: Perspective and Prospects.- New Drugs Based on Enzyme Mechanisms.- Potent and Selective Oxytocin Antagonists Obtained by Chemical Modification of a Streptomyces Silvensis Derived Cyclic Hexapeptide and by Total Synthesis.- Design of Peptide Ligands That Interact With Specific Membrane Receptors.- Organic Synthesis with Enzymes.- Stereoselective Synthesis of Biologically and Pharmacologically Important Chemical with Microbial Enzymes.- Design and Development of Enzymatic Organic Synthesis.- Enzymes as Catalysts in Carbohydrate Synthesis.- Exploiting Enzymes Selectivity for the Synthesis of Biologically Active Compounds.- Vitamin B12.- Perspectives on the Discovery of Vitamin B12.- Steric Course and Mechanism of Coenzyme B12-Dependent Rearrangements.- On the Mechanism of Action of Vitamin B12: A Non-Free Radical Model for the Methylmalonyl-CoA - Succinyl-CoA Rearrangement.- Vitamin B12: The Biosynthesis of the Tetrapyrrole Ring: Mechanism and Molecular Biology.- Biosythesis of Vitamin B12: Biosynthetic and Synthetic Researches.- On the Methylation Process and Cobalt Insertion in Cobyrinic Acid Biosynthesis.- Biochemical and Genetic Studies on Vitamin B12 Synthesis in