Chemogenomics
Methods and Applications
(Sprache: Englisch)
This book explores cutting-edge in vitro and in silico approaches available today. It also outlines aspects of chemistry, biology, and molecular informatics relevant to chemogenomics, thus combining introductory concepts with detailed methods and protocols.
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Produktinformationen zu „Chemogenomics “
This book explores cutting-edge in vitro and in silico approaches available today. It also outlines aspects of chemistry, biology, and molecular informatics relevant to chemogenomics, thus combining introductory concepts with detailed methods and protocols.
Klappentext zu „Chemogenomics “
Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment, analysis, prediction, and expansion of a comprehensive ligand-target SAR (structure-activity relationship) matrix has followed the elucidation of the human genome and presents a key scientific challenge for the twenty-first century. The anno- tion and knowledge-based exploration of the ligand-target SAR matrix is then expected to impact science greatly. Progress alongside this challenge without a doubt will c- tribute to further the fundamental understanding of the biological function of the individual proteins and ultimately provide a basis for the discovery of new and better therapies for diseases. While historically the chemogenomics approach is based on efforts that systematically explore target gene families, today broader in vitro and in silico approaches are available to encompass wider genomes. In this book, experts from academia and industry outline relevant aspects of ch- istry, biology, and molecular informatics which are the cornerstones of chemogenomics. General introductory chapters are combined with chapters describing methods and pro- cols, which are the gold standard of the Methods in Molecular Biology book series.
Inhaltsverzeichnis zu „Chemogenomics “
1. Organizing Bioactive Compound Discovery in Target FamiliesH. Peter Nestler2. Compound Library Design for Target FamiliesK. V. Balakin, Y. A. Ivanenkov, and N. P. Savchuk3. Targeting the PurinomeJeremy M. Murray and Dirksen E. Bussiere4. Cofactor ChemogenomicsRatna Singh and Andrea Mozzarelli5. Chemogenomics with Protein Secondary Structure MimeticsGarland R. Marshall, Daniel J. Kuster, and Ye Che6. Database Systems for Knowledge-Based DiscoverySarma A.R.P. Jagarlapudi and Radha Kishan K.V.7. Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein InteractionEdgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen, Caroline Engeloch, Ulrich Schopfer, Pascal Furet, Keiichi Masuya, and Joanna Lisztwan8. Off-Target Networks Derived from Ligand Set SimilarityMichael J. Keiser and Jérôme Hert9. Chemogenomic Analysis of Safety Profiling DataJosef Scheiber and Jeremy L. Jenkins10. Network and Pathway Analysis of Compound-Protein InteractionsRichard J. Brennan and Svetlana Bureeva11. The Flexible Pocketome Engine for Structural ChemogenomicsRuben Abagyan and Irina Kufareva12. Structure-Based Chemogenomics: Analysis of Protein Family LandscapesBernard Pirard13. Hypothesis-Driven ScreeningUlrich Schopfer, Caroline Engeloch, Frank Höhn, Hervé Mees, Jennifer Leeds, Fraser Glickman, Günther Scheel, Sandrine Ferrand, Peter Fekkes, and Martin Pfeifer
Bibliographische Angaben
- 2014, 320 Seiten, Maße: 26 cm, Kartoniert (TB), Englisch
- Herausgegeben:Jacoby, Edgar
- Verlag: Humana Press
- ISBN-10: 1617796395
- ISBN-13: 9781617796395
Sprache:
Englisch
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