Chemokine Biology: Basic Research and Clinical Application.Vol.2
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an...
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Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
- Chemokine biology of pulmonary diseases
- Autoimmune diseases
- Role in skin inflammation
- Transplantation
- Role in atherosclerosis
- Chemokine biology in cancer
- Chemokines as drug targets
- Targeting chemokines in multiple sclerosis
- Clinical use of CCR1 antagonist
- Small molecule CCR2 antagonist
- CCR3 inhibitors
- Targeting CCR5 for HIV therapy
- IL-8 receptor antagonist
- CXCR3 inhibitors
- CXCR4 as a therapeutic target
- Chemokines and stem cell mobilization
- Chemokine mimic-based antagonists
- 2007, 168 Seiten, Maße: 17 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: L. Gordon Letts, Kuldeep Neote
- Verlag: Birkhäuser Basel
- ISBN-10: 3764371951
- ISBN-13: 9783764371951
- Erscheinungsdatum: 19.04.2007
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