Contemporary Topics in Immunobiology

1 Cancer: A Problem in Somatic Cell Evolution.- I. Introduction.- II. Is Escape from Senescence on the Pathway to Cancer?.- III. Are Metastases or Angiogenesis on the Pathway to Cancer?.- IV. Is Anchorage-Independent Growth on the Pathway to Cancer?.- V. Can We Put Order in the Data Concerning the Immune Response to Tumors?.- VI. Natural Killer Activity and Cancer.- VII. The Bottom Line.- VIII. References.- 2 The Genetic and Cellular Basis of Regulation of the Immune Response to Tumor Antigens.- I. Introduction.- II. Cellular Interactions.- III. Genetic Basis of the Immune Response to Tumor Antigens.- IV. Effector T Cells.- V. Suppressor T Cells.- VI. Summary.- VII. References.- 3 Monoclonal Antibodies to Tumor Antigens.- I. Introduction.- II. Methodology.- III. Antigens of Mouse Tumors.- IV. Antigens of Human Tumors.- V. Conclusions.- VI. References.- 4 Continuous Cytotoxic T-Cell Lines.- I. Introduction.- II. Cytolytic T-Lymphocyte Lines.- III. Methods for Culturing T Cells.- IV. The Immunobiologic Significance of TCGF(IL2).- V. Conclusions.- VI. References.- 5 The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation.- I. Introduction.- II. Each T Lymphoma Will Bear Surface Receptors Which Specifically Recognize Its Inducing MuLV.- III. Retrovirus Receptors Can Be Used to Distinguish Incipient T Lymphomas from Other T Cells.- IV. Substances Which Interfere with Receptor Binding Inhibit T-Lymphoma Proliferation.- V. T-Lymphoma Receptors Should Have Variable Regions Analogous to Immunoglobulins and Normal T-Cell Receptors.- VI. Continuous in Vivo Antigenic Stimulation of Appropriate Normal T-Cell Clones Should Also Be Lymphomagenic.- VII. Concluding Remarks.- VIII. References.- 6 On Network Theory and H-2 Restriction.- I. Introduction.- II. The Cross-Linking Postulate and Symmetry in the System.- III. The Antigen-Specific T-Cell-Factor Postulate.- IV. The Nonspecific T-Cell-Dependent Helper Factor Postulate.- V. Summary of the Postulates of the