Deoxynucleoside Analogs in Cancer Therapy
(Sprache: Englisch)
Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for...
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Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.
Inhaltsverzeichnis zu „Deoxynucleoside Analogs in Cancer Therapy “
Nucleoside Transport into Cells: The Role of Nucleoside Transporters SLC28 and SLC29 in Cancer ChemotherapyMarcal Pastor-Anglada and F. Javier CasadoThe Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog ActivationMaria Staub and Staffan ErikssonDeoxynucleoside Kinases and Their Potential Role in Deoxynucleoside CytotoxicityBirgitte Munch-Petersen and Jure PiskurNucleotidases and Nucleoside Analog CytotoxicitySally Anne Hunsucker, Beverly S. Mitchell, and Jozef SpychalaPumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide AnalogsPiet Borst and Peter WielingaCytosine Arabinoside: Metabolism, Mechanisms, of Resistance, and Clinical PharmacologyIsabelle Hubeek, G. J. L. Kaspers, G Ossenkoppele, and G. J. PetersClofarabine: Mechanisms of Action, Pharmacology, and Clinical InvestigationVarsha Gandhi and William PlunkettL-Nucleosides as Chemotherapeutic AgentsGiuseppe Gumina, Youhoon Chong, and Chung K. ChuTroxacitabine: A Deoxycytidine Nucleoside Analogue With Potent Antitumor ActivityHenriette Gourdeau and Jacques Jolivet9-b-D-arabinofuranosylguanineSophie CurboGemcitabine: Mechanism of Action and ResistanceA. M. Bergman and G.J. PetersClinical Activity of Gemcitabine as a Single Agent and in CombinationJ. R. Kroep, GJ Peters, and RA NagourneyNucleoside RadiosensitizersDonna S. Shewach and Theodore S. LawrenceNONMEM Population Models of Cytosine Arabinoside and Flubaradine Phosphate in Pediatric Patients with LeukemiaVassilios I. AvramisThe cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral AgentsChris Meier, Jan Balzarini, and Astrid MeerbachPurine and Pyrimidine Based Analogs and Suicide GeneTherapyZoran Gojkovic3'-deoxy-3'- Fluorothymidine as a Tracer if Proliferation in Positron Emission Tomography
Bibliographische Angaben
- 2006, 2006., 476 Seiten, Maße: 16,1 x 22,6 cm, Gebunden, Englisch
- Herausgegeben:Peters, Godefridus J
- Herausgegeben: Godefridus J. Peters
- Verlag: Humana Press
- ISBN-10: 1588293270
- ISBN-13: 9781588293275
- Erscheinungsdatum: 01.09.2006
Sprache:
Englisch
Rezension zu „Deoxynucleoside Analogs in Cancer Therapy “
"...a top-notch overview of the current knowledge in the area of deoxynucleoside analog development and application in the treatment of cancer." -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal
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