Destruction of Hazardous Chemicals in the Laboratory

PREFACE xiACKNOWLEDGMENTS xiiiINTRODUCTION 1SPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 17Acetonitrile 19Acid Halides and Anhydrides 23Aflatoxins 29Alkali and Alkaline Earth Metals 37Alkali Metal Alkoxides 41Anatoxin-A 43Aromatic Amines 47Arsenic 57Azides 61Azo and Azoxy Compounds and Tetrazenes 69Boron Trifluoride and Inorganic Fluorides 77Botulinum Toxins 81Brevetoxins 85Butyllithium 89Calcium Carbide 93Carbamic Acid Esters 95Carbofuran 99Chloromethylsilanes and Silicon Tetrachloride 101N-Chlorosuccinimide and Chloramine-T 103Chlorosulfonic Acid 105Chromium(VI) 107Citrinin 113Complex Metal Hydrides 121Cyanides and Cyanogen Bromide 129Cylindrospermopsin 137Diisopropyl Fluorophosphate 141Dimethyl Sulfate and Related Compounds 151Dyes and Biological Stains 163Ethidium Bromide 201Haloethers 211Halogenated Compounds 217Halogens 229Heavy Metals 233Hexamethylphosphoramide 241Hydrazines 245Hypochlorites 257Mercury 2612-Methylaziridine 2671-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 271Microcystins 2774-Nitrobiphenyl 2833-Nitrofluoranthene and 3-Aminofluoranthene 287Nitrogen Tetroxide 291N-Nitroso Compounds: Nitrosamides 293N-Nitroso Compounds: Nitrosamines 307Ochratoxin A 319Organic Nitriles 327Osmium Tetroxide 331Palytoxin 335Patulin 339Peracids 347Perchlorates 349Peroxides and Hydroperoxides 355Phenol 359Phosgene 363Phosphorus and Phosphorus Pentoxide 367Picric Acid 371Polycyclic Aromatic Hydrocarbons 375Polycyclic Heterocyclic Hydrocarbons 387Potassium Permanganate 405b-Propiolactone 407Protease Inhibitors 411Ricin 417Saxitoxin 421Selenium Compounds 425Sodium Amide 427Sterigmatocystin 429Sulfonyl Fluoride Enzyme Inhibitors 437Sulfur-Containing Compounds 443T-2 Toxin 449Tetrodotoxin 455Triacetone Triperoxide 459Uranyl Compounds 463METHODS FOR THE DESTRUCTION OF PHARMACEUTICALS IN THE LABORATORY 467Pharmaceuticals: General Considerations 469A: Potassium Permanganate 549B: Sodium Hypochlorite 567C: Nickel-Aluminum Alloy Reduction

George Lunn, PhD, has been working as a review chemist for the FDA's Office of New Drug Quality Assessment since 1996. Previously, he was a senior research scientist in the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center. He has written nine books and over sixty papers and review articles.Eric B. Sansone, PhD, was the director of the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center until his retirement. He has also worked as a consultant in industrial hygiene and air pollution control for a widely diversified group of industries, law firms, universities, and governmental agencies. He has published many articles on the assessment of risk in cancer research.

"The book provides a good survey on destruction methods suitable for small and medium sized laboratories. The well-structured writing style provides an interesting textbook, helpful for every laboratory technician, and a reference book for supervisors responsible for the laboratory work." ("Materials and Corrosion"", "1 August 2012)"The writing is clear and precise, molecular structures and diagrams are clearly labelled, and procedures appear to be up-to-date, efficient, and adaptable . . . Summing Up: Essential. Graduate students through professionals/practitioners in academic, commercial, or industrial chemical laboratories." ("Choice", 1 November 2012)

"The book provides a good survey on destruction methods suitable for small and medium sized laboratories. The well-structured writing style provides an interesting textbook, helpful for every laboratory technician, and a reference book for supervisors responsible for the laboratory work." ( Materials and Corrosion , 1 August 2012)

"The writing is clear and precise, molecular structures and diagrams are clearly labelled, and procedures appear to be up-to-date, efficient, and adaptable . . . Summing Up: Essential. Graduate students through professionals/practitioners in academic, commercial, or industrial chemical laboratories." ( Choice , 1 November 2012)