Developments in Biotechnology and Bioprocessing

Preface; 1. Toward a Biological Replacement of Petroleum; James C. Liao; 2. Unfolded Protein Response (UPR) During CHO Cell Production Culture; Zhimei Du, David Treiber, Rebecca E. McCoy, Feng He, Amanda K. Miller,; Mei Han, Carole Heath, and Pranhitha Reddy; 3. Case Studies in the Application of Aqueous Two-Phase Processes for the; Recovery of High Value Biological Products; Karla Mayolo-Deloisa, Jose Gonzalez-Valdez, Celeste Ibarra-Herrera,; Mirna Gonzalez-Gonzalez, Carolina Garcia-Salinas, Oscar Aguilar, Jorge Benavides,; and Marco Rito-Palomares; 4. Utilizing mAb Adsorption Isotherms To Direct Process Development of a; Strong Cation-Exchange Chromatography Step; Christopher Gillespie; 5. Understanding the Role of Arginine and Citrate as Eluents in Affinity; Chromatography; Diwakar Shukla and Bernhardt L. Trout; 6. One Resin, Multiple Products: A Green Approach to Purification; Ekta Mahajan, Jay Werber, Kapil Kothary, and Tina Larson; 7. How To Tie a Peptide Knot; Si Jia Pan, Wai Ling Cheung, Siyan Zhang, Mikhail Maksimov, and A. James Link; 8. Freeze-Dry Mediated Formation of 5-(Hydroxylmethyl)furfural; Kelly Fitzpatrick, Brent Kendrick, Camilla Santos, Pat Green, Bing Zhang,; Deanna Hunt, Michael Ronk, and Ying Luo; 9. Reprogramming the Biosynthesis of Natural Products by Directed; Evolution; Gavin Williams, Irina Koryakina, John McArthur, Matthew Draelos, Shan Randal,; and David Muddimanl; 10. Image Analysis Method for Evaluating Heterogeneous Growth and; Differentiation of Embryonic Stem Cell Cultures; Megan M. Hunt, Guoliang Meng, Derrick E. Rancourt, Ian D. Gates, and; Michael S. Kallos; Editors' Biographies; Indexes; Author Index; Subject Index

Anne Kantardjieff is affiliated with Alexicon Pharmaceuticals. Prashanth Asuri is affiliated with Santa Clara University. Jonathan L. Coffman is affiliated with Pfizer, Inc. Karthik Jayapal is affiliated with Bayer HealthCare.