Developments in Tryptophan and Serotonin Metabolism

contribute to cytokine-induced anorexia.- Recent advances in physiological and pathological significance of tryptophan-NAD' metabolites: Roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis.- The endogenous formation of highly chlorinated tetrahydro-?-carbolines as a possible causative mechanism in idiopathic Parkinson 's disease.- Experimental evaluation of an altered tryptophan metabolism in fibromyalgia.- Age-related nuclear cataract and indoleamine 2,3-dioxygenase-initiated tryptophan metabolism in the human lens.- Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment.- Induction of cytochrome P450 IAl and 1B1 by photooxidized tryptophan in transformed human keratinocytes.- Prognostic value of tryptophan load test followed by serum kynurenine determination. It's comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts.- Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection.- A clinicobiochemical study of tryptophan and other plasma and urinary amino acids in the family with Hartnup disease.- The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure.- Neuropeptide-containing cells in the cortex and striatum of mice with cerebral malaria.- Tiptophan and quality of life in colorectal cancer..- Effects of chronic lung inflammation on tryptophan metabolism in piglets.- Tumor-induced changes in host metabolism: a possible rolefor free tryptophan as a marker of neoplastic disease.- Kynurenine and neopterin in the aqueous humor of the anterior chamber of the eye and in serum of cataract patients.- Mechanism of inhibitory effect of 3-hydroxykynurenine on erythropoiesis in patients with renal insufficiency.- The kynurenine pathway enzymes in healthy and hyperlipidemic rabbits.- Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits.- Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease.- Upregulation of cytochrome P450 IA2 in chronic renal failure: does oxidized tryptophan play a role?.- Kidney and liver kynurenine pathway enzymes in chronic renal failure.- Cerebral cholinergic neurotrasmission in protein and tryptophan-restricted adult rats.- Tryptophan pyrrole ring cleavage enzymes in placenta.- Increase in conversion of tryptophan to niacin in pregnant rats.- Identification and expression of a cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): A key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis.- Kynurenine pathway enzymes in different species of animals.- Kynurenine pathway enzymes in guinea pigs.- Tryptophan metabolism in rabbits.- Tryptophan metabolism along the kynurenine pathway in rats.- Enzyme activities along the kynurenine pathway in mice.- Tryptophan metabolism via transamination. In vitro amino-transferase assay using dinitrophenylhydrazine method.- Exercise, fatigue, neurotransmission and the influence of the neuroendocrine axis.- The effect of tryptophan deficiency in the brain on rat fatigue levels: a rat model of fatigue reduction.- Tryptophan metabolism was accelerated by exercise in rat.- Melatonin: detoxification of oxygen and nitrogen-basedtoxic reactants.- Mitochondrial regulation by melatonin and its metabolites.- Therapeutic effect of melatonin on cholestatic liver injury in rats with bile duct ligation.- Antioxidant and cytoprotective activity of indole derivatives related to melatonin..- Strategies leading to MT, selective melatonin receptor antagonists.- Potassium hexacyanoferrate (111)-mediated fluorometric determination of melatonin.- Melatonin in plants.- The enol tautomer of indole-3-pyruvic acid as a biological switch in stress responses.- Recent developments in marine indole alkaloid synthesis.- Modulation of the kynurenine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine- 3-hydroxylase.- Tryptophan-derived sulfur-containing phytoalexins - A general overview.- Towards enantioselective synthesis of tryptophan-derived alkaloids.- Novel bisindole derivatives of catharanthus alkaloids with potential cytotoxic properties.- Antiproliferative effect of indigoid pigments isolated from human urine.- NAD levels in the rat primary cultured hepatocytes affected by peroxisomeproliferators.- The effects of phthalate esters on the tryptophan-niacin metabolism.- 5-HT receptors mediating contraction in the rat-tail artery.- Dietary linoleic acid suppresses gene expression of rat liver a-amino-ß-carboxymuconate-e-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum.- Suitability of trypthophan radiation products as markers for the detection of y-irradiated protein-rich food.- Photochemical properties of kynurenine pathway metabolites and indoleamines.- HPLC of tryptophan and its metabolites: as OPA derivatives and on the basis of their UV and fluorescence spectra, simultaneously.- ECNI GC-MS analysis of picolinic and quinolinic acids and theiramides in human plasma, CSF and brain tissue.- Drosophila mutants of the kynurenine pathway as a model for ageing studies.- Involvement of 5-hydroxytryptophan in melanogenesis.- Interaction of 7-azatryptophan and ß(1-azulenyl)-alanine with a nitroxyl radical.- HPLC profiling of Trp-related metabolites in humans.- 6-Nitrotryptophan: a specific reaction product of tryptophan residue in human Cu, Zn-SOD treated with peroxynitrite.- Bioadhesive topical application of tryptophan derivatives.- Serum tryptophan and 5-hydroxytryptophan at birth and during post-partum days.- Closing Remarks.- Author Index.