Diabetes, Insulin and Alzheimer's Disease
(Sprache: Englisch)
This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
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This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
Klappentext zu „Diabetes, Insulin and Alzheimer's Disease “
The central nervous system controls vital functions by ef?ciently coordinating peripheral and central cascades of signals and networks in an orchestrated manner. Historically, the brain was considered to be insulin independent. These earlier views have been challenged by ?ndings demonstrating that insulin exerts multiple actions in the brain, regulating vital biological processes such as life span, neuronal survival, cognition, reproduction, feeding behavior, energy balance, and glucose and fat metabolism, and that inef?cient central action of insulin contributes to the development of severe pathologies (Banks et al. 2000; Gerozissis 2003, 2004, 2008; Lustman and Clouse 2005; Okamoto et al. 2001; Park 2002; Perrin et al. 2004; Pocai et al. 2005; Reger et al. 2008; Schwartz and Porte, 2005; Schubert et al. 2004; van der Heide et al. 2005; Woods et al. 1979; Wrighten et al. 2008). Insulin and speci?c insulin receptors are widely distributed in the networks of the central nervous system related mainly to feeding or cognition (Baskin et al. 1983; Bruning et al. 2000; Gerozissis 2003, 2008; Havrankova et al. 1978a, b; Schechter et al. 1996; Schulingkamp et al. 2000; Schwartz et al. 1992; Zhao et al. 2004). Insulin receptors located in the synapses of neurons and in astrocytes are present in high concentrations in the cerebral cortex, olfactory bulb, hippocampus, amygdala, cerebellum and hypothalamus (Abbott et al., 1999; Havrankova et al.
Inhaltsverzeichnis zu „Diabetes, Insulin and Alzheimer's Disease “
Insulin Action in the Brain and the Pathogenesis of Alzheimer's Disease by Carl Ronald Kahn and Ryo Suzuki.- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies by Kyriaki Gerozissis.- Insulin Mediated Neuroplasticity in the Central Nervous System by Lawrence P. Reagan.- Stress Hormones and Neuroplasticity in the Diabetic Brain by Alexis M. Stranahan and Mark P. Mattson.- Diabetes and the Brain - an Epidemiologic Perspective by Lenore J. Launer.- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors by Geert Jan Biessels.- The Relationship between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer's disease: an Epidemiological Perspective byJosé A. Luchsinger.- The Role of Insulin Dysregulation in Aging and Alzheimer's disease by Suzanne Craft.- Is Alzheimer's a Disorder of Ageing and why don't Mice get it? The Centrality of Insulin Signalling to Alzheimer's disease Pathology by Simon Lovestone and Richard Killick.- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD by Miao-Kun Sun, Thomas J. Nelson and Daniel L. Alkon.- Diet, Aß Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimer's disease by Greg M. Cole, Qiu-Lan Ma, Fusheng Yang, Atul Deshpande, Oliver Ubeda and Sally A. Frautschy.- Serum IGF-I, Life-style, and Risk of Alzheimer¿s disease by Joaquin Piriz, Takeshi Nishijima, Jose Luis Trejo and Ignacio Torres Aleman.- Subject index.
Bibliographische Angaben
- 2010, 218 Seiten, 21 farbige Abbildungen, 9 Schwarz-Weiß-Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Suzanne Craft, Yves Christen
- Verlag: Springer
- ISBN-10: 3642042996
- ISBN-13: 9783642042997
- Erscheinungsdatum: 05.03.2010
Sprache:
Englisch
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