Diastolic Relaxation of the Heart

Preface. Part I: Molecular Biology of Relaxation. 1. Overview: the Molecular Phenotype of Normal and Impaired Relaxation; K. Schwartz, K.R. Boheler. 2. Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Program; A.M. Feldman, V.T. Edwards, J.E. Lawrence, W.D. Rosenblum, R.E. Williams. 3. Sarcoplasmic Reticulum Gene Expression in Human Heart Failure; M. Periasamy, M. Arai. 4. Molecular Aspects of the Control of Myocardial Relaxation; I. Shiojima, I. Komuro, T. Yamazaki, R. Nagai, Y. Yazaki. 5. Molecular Physiology of Ventricular Hypertrophy; K.R. Chien. Part II: Consequences of Altered Gene Expression: the Economy of Diastole. 6. Regulatory Proteins and Diastolic Relaxation; R.J. Solaro, B.M. Wolska, M. Westfall. 7. Intracellular Free Calcium in Hypertrophy and Failure; J.K. Gwathmey, R. Liao, R.J. Hajjar. 8. A Molecular Biophysical Approach to Contraction and Relaxation; N.R. Alpert, J.N. Peterson. 9. On the Relations among ATP Hydrolysis, Cation Accumulation and Diastolic Dysfunction; M. Bernard, S. Neubauer, J.S. Ingwall. 10. Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastole; J.D. Marsh. 11. The Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failure; B.H. Lorell. 12. Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart. Relevance of SR-Ca2+-ATPase Protein Levels; G. Hasenfuss, H. Reinecke, R. Studer, H. Drexler, B. Peiske, C. Holubarsch, H. Holtz, N.R. Alpert, H. Just. Part III: Impaired Relaxation in Experimental Models: Ischemia and Hypoxia. 13. Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Model; J.P. Morgan, K. Harada, A. Meissner, C. Williams, H.P. Carrozza, L.A. Bentivegna, Y. Kihara, W. Grossman. 14. Diastolic Dysfunction during Ischemia: Role of Glycolytic ATP Generation; C.S. Apstein. 15. Does Calcium Overload Adequately Explain Diastolic Dysfunction during