Drug Receptor Interactions in Antimicrobial Chemotherapy

I. Receptor Hypothesis.- Structure-Activity Rules and the Receptor Hypothesis.- Strategy of Drug-Design.- Physicochemical Factors in Drug-Receptor Interactions Demonstrated on the Example of the Sulfanilamides.- Quantitative Structure-Activity Relationships in Drug-Design.- II. DNA as a Drug-Receptor.- The Ecological Significance of R Factor Activity.- Structural Constraints in the Binding of Drugs to DNA.- Molecular Aspects of the Biosynthesis of R Factor DNA.- Elimination of Plasmidic Determinants by DNA-Complexing Compounds.- III. Ribosomes as Drug-Receptors.- Antibiotic Receptor-Sites in Escherichia coli Ribosomes.- Altered Methylation of Ribosomal RNA in Erythromycin-Resistant Staphylococcus Aureus.- Binding of Tetracyclines and Other Antibiotics to Ribosomes.- Ribosomal Effects of Thiostrepton and Related Antibiotics.- Studies on Active Sites of Ribosomes with Haloacetylated Antibiotic Analogs.- IV. The Mode of Action of Chloramphenicol.- Antibiotic Action on the Ribosomal Peptidyl Transferase Centre.- Experiments on the Binding Sites and the Action of Some Antibiotics which Inhibit Ribosomal Functions.- The Mode of Action of Pleuromutilin as Compared to Chloramphenicol.- A Structural Model of the Chloramphenicol Receptor Site.- V. Microbial Enzyme as Drug-Receptors.- Spin-Labelled Intermediates as Targets of Antibiotic Action in Peptidoglycan Synthesis.- Enzyme Inhibitors as Antimicrobial Agents.- Molecular Mechanism of Action of Rifamycins.- List of Participants.- List of Authors.