Epigenetics of Autoimmune Diseases
(Sprache: Englisch)
The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often...
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The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases.
Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field.
Specific coverage includes:
* How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants.
* Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis.
* How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation.
* Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases.
This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.
The book will cover the latest discoveries and developments in epigenetics and their significance in a variety of autoimmune diseases including rheumatoid arthritis, autoimmune anaemia, type-1 diabetes, multiple sclerosis, autoimmune gastritis, thyroiditis, and systemic lupus erythematosus. The book will contain approximately 30 chapters written by world-class experts in their respective fields and divided into four parts:
(i) Transcription factors - partners of immune tolerance to self
(ii) Epigenetic modifiers of autoimmunity
(iii) Influence of environmental factors on epigenetics of autoimmunity
(iv) Stress responses that break immune silence.
(i) Transcription factors - partners of immune tolerance to self
(ii) Epigenetic modifiers of autoimmunity
(iii) Influence of environmental factors on epigenetics of autoimmunity
(iv) Stress responses that break immune silence.
Inhaltsverzeichnis zu „Epigenetics of Autoimmune Diseases “
Contributors.PART I: TRANSCRIPTION FACTORS: PARTNERS OF IMMUNE TOLERANCE TO SELF.
1. Transcriptional Regulation of T Cell Tolerance (Brian T. Abe, Ayana Jordan, Vanessa M. Hubbard and Fernando Macian).
References.
2. Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells (Julia K. Polansky, Stefan Floess, Jennifer Freyer, Alf Hamann and Jochen Huehn).
References.
3. The Role of NF-8B in Central Tolerance (Mingzhao Zhu, Matthew Ruddy and Yang-Xin Fu).
References.
4. The Role of Act1 in the Control of Autoimmunity (Trine N. Jörgensen, Natalia V. Giltiay, Angela Johnson and Xiaoxia Li).
References.
5. Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b (Stefanie Loeser and Josef M. Penninger).
References.
6. Indoleamine 2,3-dioxygenase: Transcriptional Regulation and Autoimmunity (Maria Laura Belladonna, Ciriana Orabona, Claudia Volpi, Ursula Grohmann, Paolo Puccetti and Maria Cristina Fioretti).
References.
PART II: STRESS RESPONSES THAT BREAK IMMUNE SILENCE.
7. Chromatin Modifications, Oxidative Stress and Nucleosome Autoantibodies (Annika Erbacher and Patrice Decker).
References.
8. Stress, Epigenetics and Thyroid Autoimmunity (Agathocles Tsatsoulis).
References.
9. Reactive Intermediates, Inflammation and Epigenetics in Lupus (Gary S. Gilkeson and Jim C. Oates).
References.
10. Post-translational Modification of HMGB1 and Its Role in Immune Activation (Anirudh J. Ullal and David S. Pisetsky).
References.
11. Idiosyncratic Drug-Induced Liver Injury: Facts and Perspectives (Jos,. V. Castell and Isabel Miñana).
References.
PART III: EPIGENETIC MODIFIERS OF AUTOIMMUNITY.
12 Epigenetic Modifications Associated with T Cell Tolerance (Andrew D. Wells and Rajan M. Thomas).
References.
13. DNA Methylation Alterations in Systemic Lupus Erythematosus (Biola M. Javierre, Manel Esteller and Esteban Ballestar).
References.
14 Long-Range Histone
... mehr
Acetylation Patterns in the Development of Autoimmunity (Thomas M. Aune, Shaojing Chang and Weisong Zhou).
References.
15. Roquin Defects Reveal a Role for the microRNA Machinery in Regulating Autoimmunity (Di Yu and Carola G. Vinuesa).
References.
16. Autoimmune Response to Post-translationally Modified (Citrullinated) Proteins: Prime Suspect in the Pathophysiology of Rheumatoid Arthritis (Mireille Sebbag, Cyril Clavel, Leonor Nogueira, Jacques Arnaud and Guy Serre).
References.
17. Hormones: Epigenetic Contributors to Gender-Biased Autoimmunity (Virginia Rider and Nabih I. Abdou).
References.
18. Epigenetics and Systemic Sclerosis (Serena Guiducci and Marco Matucci Cerinic).
References.
19. Epigenetic Regulation of B Lymphocyte Development and Repertoire Selection: Relevance to Autoimmunity (Moncef Zouali).
References.
PART IV: TOWARDS NOVEL EPIGENETIC-BASED IMMUNO-INTERVENTION STRATEGIES IN AUTOIMMUNE DISEASE.
20. Protective Effects of Epigenetic Modifications in Experimental Inflammatory Bowel Disease (Rainer Glauben, Elena Sonnenberg and Britta Siegmund).
References.
21. Epigenetic Regulation of Autoimmune Diseases through Deacetylase Inhibition (Bin Li, Yuan Shen, Zhaocai Zhou, Xiaomin Song, Kathryn Bembas, Xiao Yun Zhao, Zheng Cai, Alan Berezov, Sandra J. Saouaf, Hongtao Zhang, Qiang Wang and Mark I. Greene).
References.
22. Histone Deacetylases and Autoimmunity (András Treszl, GergQ Mészáros, Gergely Toldi and Barna Vásárhelyi).
References.
23. Histone Deacetylase Inhibitors as a Therapeutic Modality in Multiple Sclerosis (Steven G. Gray).
References.
Index., 20090129
References.
15. Roquin Defects Reveal a Role for the microRNA Machinery in Regulating Autoimmunity (Di Yu and Carola G. Vinuesa).
References.
16. Autoimmune Response to Post-translationally Modified (Citrullinated) Proteins: Prime Suspect in the Pathophysiology of Rheumatoid Arthritis (Mireille Sebbag, Cyril Clavel, Leonor Nogueira, Jacques Arnaud and Guy Serre).
References.
17. Hormones: Epigenetic Contributors to Gender-Biased Autoimmunity (Virginia Rider and Nabih I. Abdou).
References.
18. Epigenetics and Systemic Sclerosis (Serena Guiducci and Marco Matucci Cerinic).
References.
19. Epigenetic Regulation of B Lymphocyte Development and Repertoire Selection: Relevance to Autoimmunity (Moncef Zouali).
References.
PART IV: TOWARDS NOVEL EPIGENETIC-BASED IMMUNO-INTERVENTION STRATEGIES IN AUTOIMMUNE DISEASE.
20. Protective Effects of Epigenetic Modifications in Experimental Inflammatory Bowel Disease (Rainer Glauben, Elena Sonnenberg and Britta Siegmund).
References.
21. Epigenetic Regulation of Autoimmune Diseases through Deacetylase Inhibition (Bin Li, Yuan Shen, Zhaocai Zhou, Xiaomin Song, Kathryn Bembas, Xiao Yun Zhao, Zheng Cai, Alan Berezov, Sandra J. Saouaf, Hongtao Zhang, Qiang Wang and Mark I. Greene).
References.
22. Histone Deacetylases and Autoimmunity (András Treszl, GergQ Mészáros, Gergely Toldi and Barna Vásárhelyi).
References.
23. Histone Deacetylase Inhibitors as a Therapeutic Modality in Multiple Sclerosis (Steven G. Gray).
References.
Index., 20090129
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Bibliographische Angaben
- Autor: Zouali
- 2009, 472 Seiten, Maße: 17,5 x 24,9 cm, Gebunden, Englisch
- Herausgegeben: Moncef Zouali
- Verlag: John Wiley & Sons
- ISBN-10: 0470758619
- ISBN-13: 9780470758618
Sprache:
Englisch
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