Experimental Design and Reproducibility in Preclinical Animal Studies
(Sprache: Englisch)
This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the...
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Klappentext zu „Experimental Design and Reproducibility in Preclinical Animal Studies “
This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process.
The book addresses advanced undergraduates, graduate students and all scientists working with animals.
Inhaltsverzeichnis zu „Experimental Design and Reproducibility in Preclinical Animal Studies “
1. An introduction to reproducibility in the context of animal research
2. Rodent Genetics
2.1. Introduction to Mendelian genetics and genomics
2.2. Standardized strains of laboratory rodents
2.3. Genetically altered (GA) rodents 2.4. Genetic quality control for mice and rats
2.5. Mouse and rat phenomics
3. Animal and environmental factors that influence reproducibility
4. Microbiology and Microbiome
5. Effects of untreated pain, anesthesia and analgesia in animal experimentation
6. Why do we need a statistical experiment design?
7. Statistical tests and Sample size calculations
8. Design of experiments
9. Scholarly Publishing and Scientific Reproducibility
10. Systematic reviews
11. Planning animal experiments
Autoren-Porträt
José M. Sánchez Morgado, DVM, MSc, PhD, Dip. ECLAM qualified as veterinarian at the Universidad Complutense of Madrid. He is European Veterinary Specialist in Laboratory Animal Medicine and Veterinary Council Ireland recognised Specialist in Laboratory Animal Medicine. Dr. Sánchez Morgado is currently Director of Comparative Medicine and Adjunct Associate Professor at Trinity College Dublin. He is also one of the Editors in Chief of the Laboratory Animals journal. Dr. Sánchez Morgado described a case of non-human primate intersex in 2003. Furthermore, he published studies on virulence of canine coronaviruses, Mycobacterium gordonae infection of amphibians, and on diagnostic discrepancies of Helicobacter spp., a common rodent pathogen, by different laboratories, and a new helicobacter diagnostic assay. He has worked as Designated Veterinarian in the UK, Spain and the Republic of Ireland, and has managed two laboratory animal care and user programs.
Bibliographische Angaben
- 2021, 1st ed., 277 Seiten, mit farbigen Abbildungen, Maße: 25,4 cm, Gebunden, Englisch
- Herausgegeben:Sánchez Morgado, José M.; Brønstad, Aurora
- Verlag: Springer
- ISBN-10: 3030661466
- ISBN-13: 9783030661465
Sprache:
Englisch
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