Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
(Sprache: Englisch)
In this study, we present novel insights into mechanisms that account for the ER -dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER...
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In this study, we present novel insights into mechanisms that account for the ER -dependent myocardial protection against myocardial injury, with more beneficial effects in female hearts. Using a transgenic mouse model with a cardiomyocyte-specific ER -overexpression (ER -OE), we first demonstrated that this was associated with an increase of LVM at the basal level in both female and male mice. After MI, the cardiomyocyte-specific ER -OE inhibited changes in LV-volumes and wall thickness only in female mice. These beneficial effects in female ER -OE hearts were associated with increased angiogenesis and lymphangiogenesis, attenuated ventricular fibrosis and enhanced JNK phosphorylation. This study indicates that in the female sex, ER in cardiomyocytes may have a therapeutic potential in the treatment of ischemic heart disease, leading to more efficient cardiac repair after ischemic injury.
Bibliographische Angaben
- Autor: Xiang Zhang
- 2015, 92 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: Presses Académiques Francophones
- ISBN-10: 3838151283
- ISBN-13: 9783838151281
Sprache:
Englisch
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