From Molecular to Modular Tumor Therapy:

- Introduction

1. Bridging theory and therapeutic practice:From generalized disease models to particular patient

Part I; Therapy-derived systems biology: A pragmatic communication theory
2. Tumor systems need to be rendered usable for a new action-theoretical abstraction:The starting point for novel therapeutic options
3. Principles of modular tumor therapy

Part II; Tumors share common processes during tumor evolution:Communicative aspects of a situation's interpretationfor creating systems-directed therapies
4. Coagulation Cancer and Coagulation; focusing on tissue factor and heparanase
5. The role of mesenchymal cells in cancer: contribution to tumor stroma and tumorigenic capacity
6. Shaping Tumour Associated Macrophages: The Role of NF-?B
7. The metabolic Achilles heel: tumor cell metabolism as therapeutic target
8. Could be systems-directed therapy approaches promising in glioblastoma patients?

Part III; Systems-relevant molecular and cellular targets:Implementation of modular 'knowledge'(Integration of communication)
9. Functional impacts of signal integration: Regulation of inflammation-related transcription factors by heterotrimeric G proteins
10. Molecular cross-talk between nuclear receptors and nuclear factor-?B
11. The biomodulatory capacities of low-dose metronomic chemotherapy: complex modulation of the tumor microenvironment

Part IV; Tumors are evolvable modular and rationalized systems:From molecular to modular tumor therapy
12. Systems biology: A therapeutic target for tumor therapy
13. The comparative uncovering of tumor systems biology by modularly targeting tumor-associated inflammation
14. Searching for the 'metabolism' of evolution

Part V. Biomodulatory therapy approaches in metastatic cancer
15. Therapeutic inflammation control may impact pathways ultimately determining outcome
16. Cholangiocellular carcinoma
17. A secretome-derived biomarker, C-reactive protein as response parameter to biomodulatory therapy