Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer

From a prospective point of view, the association between fruit and vegetable consumption and risk of ovarian cancer remains unclear. Therefore, the present study was to investigate the association between consumption of fruits and vegetables and risk of the development of epithelial ovarian cancer in a multi-center large scale cohort study. Special attention was paid to the evaluation of the impact of calibrating multi-center dietary data. High consumption of fruits and vegetables did not reduce the risk of developing ovarian cancer. There was suggestive indication for a positive association with risk of ovarian cancer among very low fruit and vegetable consumers. Also, data indicated an inverse association between a high consumption of garlic and onion vegetables and ovarian cancer risk. The calibration of dietary data was found to have a remarkable impact on absolute intake values. However, the impact on risk estimates was rather small. The study of the histologic subtype of the tumor in relation to fruit and vegetable consumption as well as the study of vegetable subgroup consumption and ovarian cancer risk warrants further investigation.