Functional Neural Transplantation III.Vol.3/2

1. Preface


Stephen Dunnett and Anders Björklund


2. Transplantation in the Future


Fred H. Gage

Stroke


3. Neural Differentiation and Support of Neuroregeneration of Non-Neural Adult Stem Cells


Rojin Abraham and Catherine M. Verfaillie


4. Stem Cell Repair of Striatal Ischemia


Zaal Kokaia and Olle Lindvall


5. In-vivo Imaging of Cell Transplants in Experimental Ischemia


Joanna Adamczak and Mathias Hoehn


6. Bone Marrow Stem Cells in Experimental Stroke


Jeffery D. Kocsis and Osamu Honmou


7. Advantages and Challenges of Alternative Sources of Adult-Derived Stem Cells for Brain Repair in Stroke


Paul R. Sanberg, David J. Eve, Christopher Metcalf and Cesario V. Borlongan


8. Prospects for Stem Cell-Derived Therapy in Stroke


John D. Sinden, Indira Vishnubhatla and Keith W. Muir

Retinal and Cortical Repair


9. Generation of Retinal Cells from Pluripotent Stem Cells


Zi-Bing Jin and Masayo Takahashi


10. Generation of Cortical Neurons from Pluripotent Stem Cells


Pierre Vanderhaeghen

Spinal Cord Repair


11. A Glio-Centric View of Repair


Ying Li, Daqing Li and Geoffrey Raisman


12. Current Status of Myelin Replacement Therapies in Multiple Sclerosis


Jeffrey K. Huang and Robin J.M. Franklin


13. Stem Cell-Based Treatments for Spinal Cord Injury


Lindsey A. Wyatt and Hans S. Keirstead


14. The challenges of Long-Distance Axon Regeneration in the Injured CNS


Daniel J. Chew, James W. Fawcett and Melissa R. Andrews


15. Schwann Cell Transplantation: A Repair Strategy for Spinal Cord Injury?


Ryan R. Wiliams and Mary Bartlett Bunge


16. Generation of Motor Neurons from Pluripotent Stem Cells


Peter H. Chipman, Jeremy S. Toma and Victor F. Rafuse


17. Transplantation of Mesenchymal Stem Cells in ALS Letizia Mazzini, Alessandro Vercelli, Ivana Ferrero, Marina Boido, Roberto Cantello and Franca Fagioli

Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington's disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson's disease. As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund's lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson's disease) in patients