Genetics

Genetics: The Study of Biological Information PART I Basic Principles: How Traits Are Transmitted 2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity 3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype 4 The Chromosome Theory of Inheritance 5 Linkage, Recombination, and the Mapping of Genes on Chromosomes PART II What Genes Are and What They Do 6 DNA: Structure, Replication, and Recombination 7 Anatomy and Function of a Gene: Dissection Through Mutation 8 Gene Expression: The Flow of Information from DNA to RNA to Proteinv PART III Analysis of Genetic Information 9 Digital Analysis of DNA 10 Genomes and Proteomes 11 Genome-Wide Variation and Trait Analysis PART IV How Genes Travel on Chromosomes 12 The Eukaryotic Chromosome 13 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes 14 The Prokaryotic Chromosome: Genetic Analysis in Bacteria PART V How Genes Are Regulated 15 Gene Regulation in Prokaryotes 16 Gene Regulation in Eukaryotes 17 Somatic Mutation and the Genetics of Cancer 18 Using Genetics to Study Development PART VI Genetics Beyond the Individual 19 Variation and Selection in Populations 20 Evolution at the Molecular Level PART VIII Systems Biology 21 Systems Biology and the Future of Medicine

Dr. Leland H. Hartwell received his Ph.D from MIT. He has held Assistant and Associate Professorships at the University of California before joining the faculty of the University of Washington, where he continues as a Full Professor. In 1996, Dr. Hartwell joined the Fred Hutchinson Cancer Research Center as a Full Member and Senior Advisor for Scientific Affairs, and was named President and Director of the Center in July, 1997. Dr. Hartwell has received numerous awards and honors in the course of his career. Among them he received the Brandeis university Rosenteil Award in 1993, and the sloan-kettering Cancer Center Katherine Berkan Judd Award as well as the Genetics Society of America Medal in 1994. In 1995 he was awarded the MGH Warren Triennial Price and in 1996 was awarded the Columbia University Horwitz Award and the Passano Award. Dr. Hartwell received the Albert Lasker Award for medical research in 1998.Dr. Michael Goldberg is a professor at Cornell University where he teaches introductory Genetics. He was an undergraduate at Yale University, and received his PhD in Biochemistry from Stanford University. Dr. Goldberg performed postdoctoral research at the Biozentrum of the University of Basel (Switzerland), posdoctoral research at the Biozentrum of the University of Basel and at Harvard University, and received an NIH Fogarty Senior International Fellowship for study at Imperial College (England) and at the University fo Rome (Italy). His current research utilizes the tools of Drosophila genetics to investigate the mechansims that ensure proper chromosome segregation during mitosis and meiosis.