Glycoscience
As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical...
As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world's leading researchers in the field.
1.1 Structure and Conformation of Carbohydrates
1.2 General Occurance and Properties of Carbohydrates
2 General Synthetic Methods
2.1 Reactions at Oxygen Atoms
2.2 Oxidation, Reduction and Deoxygenation
2.3 Heteroatom Exchange
2.4 Anhydrosugars
2.5 C-C Bond Formation
2.6 C=C Bond Formation
2.7 Degradations and Rearrangement Reactions
3 Chemical Glycosylation Reactions
3.1 Introduction to Glycosylation Reactions
3.2 Glycosyl Halides
3.3 Glycosyl Trichloroacid Imidates
3.4 Other Anomeric Esters
3.5 O-Glycosyl Donors
3.6 S-Glycosylation
3.7 Glycal Derivatives
3.8 Anomeric Anhydro Sugars
3.9 C-Glycosylation
4 Monosaccharides
4.1 Occurance, Significance and Properties
4.2 Monosaccharides and Polyols in Foods
4.3 De Novo Synthesis of Monosaccharides
4.4 Monosaccharides as Chiral Pools for the Synthesis of Complex Natural Compounds
4.5 Monosaccharides as Scaffolds for the Synthesis of Novel Compounds
4.6 Monosaccharides as Chiral Auxiliaries and Ligands for Asymmetric Synthesis
4.7 Carbohydrate Metal Complexes
5 Oligosaccharides
5.1 Occurrence, Significance and Properties
5.2 Sucrose and Related Oligosaccharides
5.3 Oligosaccharides in Food and Agriculture
5.4 Combinatorial Methods in Oligosaccharide Synthesis
5.5 Solid Phase Methods
5.6 Stereoselective Synthesis of ß-Manno Glycoside
5.7 Silalylation
5.8 Enzymatic Glycosylation by Tranferases
5.9 Enzymatic Glycosylation by Hydrolases
6 Complex Polysaccharides
6.1 Occurence, Significance and Properties
6.2 Starch
6.3 Cellulose and Hemicellulose
6.4 Gums and Related Polysaccharides
6.5 Bacterial Cell Wall Components
6.6 Fungal Cell Wall Components
6.7 Structure-Activity Relationship of Glycosaminoglycans
7 Glycolipids
7.1 Occurence, Significance and Properties
7.2 Synthesis
7.3 Biosynthesis and Degradation
7.4 Glycosylphosphatidylinositols
8 Glycoproteins
8.1 Occurence and Significance
8.2 Properties
8.3 Synthesis and Applications of Biologically
8.4 Glycosilylation Engineering of Glycoproteins
8.5 Glycoprotein Analysis
9 Glycomimetics
9.1 Azaglycomimetics: Synthesis and Chemical Biology
9.2 Carbasugars: Synthesis and Functions
9.3 Sulfur Containing Glycomimetics
9.4 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids
9.5 Non-Sugar Glycomimetics
10 Key Technologies and Tools for Functional Glycobiology
10.1 Introduction
10.2 Microarrays
10.3 Chemical Probes and Monitoring
10.4 Glycomics and Mass Spectrometry
10.5 Bioinformatical Tools
11 Biosynthesis and Degradation
11.1 Introduction
11.2 Biosynthesis and Degradation of Monosaccharides
11.3 Biosynthesis of Oligosaccharides and Polysaccharides
11.4 Degradation of Oligosaccharides and Polysaccharides
12 Glycomedicine
12.1 Novel Approaches for Glycodrug Discovery
12.2 Biomedicine of Monosaccharides
12.3 Mammalian Carbohydrate-Lectin Interactions
12.4 Multivalency in Protein-Carbohydrate Recognition
12.5 Synthesis of Heparin-Fragments
12.6 Biomedicine of Glycolipids and Glycosphingolipids
12.7 Biomedicine of Enkephalin-Derived Glycopeptide Analgesics
12.8 Antitumor and Antimicrobial Glycoconjugates
12.9 Biomedicine of Glycosylated Natural Compounds
12.10 Mucin-based Vaccines
12.11 Polysaccharide-based Vaccines
- 2nd ed. 2008, xcvi, 2874 Seiten, 638 Schwarz-Weiß-Abbildungen, Maße: 17,8 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Bertram O. Fraser-Reid, Kuniaki Tatsuta, J. Thiem
- Verlag: Springer, Berlin
- ISBN-10: 354036157X
- ISBN-13: 9783540361572
- Erscheinungsdatum: 08.05.2008
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