Handbook of Pancreatic Cancer

Section One: The Nature of Pancreatic Cancer Epidemiology: world overview, risk factors, prospects for preventionDevelopment and structure of pancreasPathologic classification and biological behaviour of pancreatic neoplasiaDevelopmental molecular biology of the pancreasMolecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancerMolecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, NeurofibromatosisSporadic neuroendocrine pancreatic tumoursMolecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancerMiscellaneous non-pancreatic non-endocrine tumoursNovel molecular relationships between chronic pancreatitis and cancerPancreatic cancer stem cellsCell cycle control: signalling pathways in pancreatic pathogenesisApoptosis: signalling pathways in pancreatic pathogenesisEGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK Hedgehog: signalling pathways in pancreatic pathogenesisSmad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesisNotch signalling in pancreatic morphogenesis and pancreatic cancerMolecular characterization of pancreatic cell linesMouse models of exocrine pancreatic cancer Principles and applications of microarray gene expression in pancreatic cancerPrinciples and applications of proteomics in pancreatic cancer Tumour-stromal interaction: invasion and metastasesGenetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromesInherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and

John Neoptolemos is Professor of Surgery and Head of the Division of Surgery and Oncology at the University of Liverpool and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. As an undergraduate he studied Natural Sciences at Cambridge (BA 1973, MA 1976) before completing his clinical undergraduate training at Guys Hospital (Cambridge: MB, BChir 1976). He completed his academic and clinical training in Leicester under Prof. Sir Peter Bell, being awarded a Doctorate in Medicine in 1986.Raul A. Urrutia, M.D., Mayo Clinic College of Medicine, Rochester, MN USA. Dr. Urrutia was awarded his M.D., Magna Cum Laude, by the University of Cordoba, Argentina. Dr. James L. Abbruzzese is the Chairman of the Department of Gastrointestinal Medical Oncology at the University of Texas M. D. Anderson Cancer Center, Houston, Texas, where he holds the Annie Laurie Howard Research Distinguished Professorship. Author of over 150 original articles and book chapters, Dr. Abbruzzese has recently been appointed the Editor-in-Chief of the International Journal of Pancreatology. He serves on the editorial board of a number of prestigious journals, including the Journal of Clinical Oncology and Clinical Cancer Research, and also serves on the Scientific Advisory Board of the Lustgarten Foundation for Pancreatic Cancer Research.Markus W. Büchler is Professor of Surgery at the University of Heidelberg, Germany. He studied medicine at the Universities of Heidelberg and Berlin and was trained in surgery at the Department of Surgery, University of Ulm, where he was appointed a Consultant Surgeon in 1987 and Vice Chairman in 1991. Professor Büchler is a specialist in hepato-pancreato-biliary surgery (HPB) and, in particular, pancreatic surgery. He has a substantial curriculum of scientific publications in the field of HPB diseases, especially in translational research of pancreatic cancer. He is Editor or Editorial Board member of many leading journals in general and