Mass Spectrometry of Proteins and Peptides in Drug Discovery
(Sprache: Englisch)
With chapters provided by international leading experts, Mass Spectrometry of Peptides and Proteins in Drug Discovery covers the most recent advancements in this area. Focusing on the pharmaceutical industry, the book addresses both emerging mass...
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Produktinformationen zu „Mass Spectrometry of Proteins and Peptides in Drug Discovery “
With chapters provided by international leading experts, Mass Spectrometry of Peptides and Proteins in Drug Discovery covers the most recent advancements in this area. Focusing on the pharmaceutical industry, the book addresses both emerging mass spectrometry techniques, including imaging mass spectrometry, H/D exchange, ion mobility, and microwave-assisted mass spectrometry, and recent applications, including biomarkers and inhibitor screening. The book is written with an industry perspective and provides real world examples.
Klappentext zu „Mass Spectrometry of Proteins and Peptides in Drug Discovery “
Recent advances in ionization techniques and mass spectrometry instrumentation have revolutionized applications of mass spectrometry in the characterization of proteins and peptides. Many of these advances have contributed greatly to the analysis of a wide rage of compounds encountered in pharmaceutical research and development. Withinthe last five years, new mass spectrometry strategies and methodologies have been introduced to enhance our understanding of biological processes involving normal and disease states. These methods provide future potential in clinical applications and, thereby, to meet challenges in drug discovery process.With chapters provided by international leading experts, Mass Spectrometry of Peptides and Proteins covers the most recent advancements in this area. Focusing on the pharmaceutical industry, the book addresses both emerging mass spectrometry techniques, including imaging mass spectrometry, H/D exchange, ion mobility, and microwave-assisted mass spectrometry, and recent applications, including biomarkers and inhibitor screening. The book is written with an industry perspective and provides real world examples.
Inhaltsverzeichnis zu „Mass Spectrometry of Proteins and Peptides in Drug Discovery “
* Overview of protein mass spectrometry.This chapter will give an overview on ionization methods, MS instrumentation and general strategies related to proteins / peptides analysis..
* Recombinant proteins and post-translationally modified proteins.
This chapter will present MS studies on characterization of recombinant proteins, therapeutic proteins, and post-translational modified proteins such as glycol-proteins, phosphorylated proteins. The discussion will also focus on micro-heterogeneity in protein bulk drug, specific strategies for enhancing yield of recombinant protein production..
* Proteomics in drug discovery.
This chapter will cover identification, quantification and characterization of proteins in global analysis of gene expression related to target proteins in drug discovery. These studies can provide comparative information on proteins and protein modifications found in disease samples with respect to those in healthy samples..
* Protein-ligand interaction and inhibitor screening.
This chapter will describe non-covalent complexes between target proteins and ligands as well as inhibitor screening in drug discovery..
* Proteins / peptides biomarkers.
This chapter will detail applications of biomarkers with respect to disease states, clinical experiments and toxicology studies..
* Microwave-assisted MS.
This chapter will illustrate principles and applications of microwave-assisted reactions, followed by mass spectrometric analysis in characterizing proteins and peptides. Using this novel approach, reactions (i.e. enzymatic digestion) can be carried out in minutes, in contrast to the hours required by conventional methods..
* Imaging MS.
This chapter will provide fundamentals and applications of imaging MS techniques in determining or mapping of proteins and peptides in tissue sections of biological samples. This is a relatively new technique which can be used to characterize the expression of proteins and other
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biological compounds in normal and disease tissues..
* Protein conformation : H/D exchange & ion mobility.
This chapter will deal with protein folding / unfolding using H/D exchange and ion mobility techniques., 20080806
* Protein conformation : H/D exchange & ion mobility.
This chapter will deal with protein folding / unfolding using H/D exchange and ion mobility techniques., 20080806
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Autoren-Porträt
Birendra N. Pramanik, PhD, was a Distinguished Fellow at Schering-Plough Research Institute (SPRI), where he directed the spectroscopy, mass spectrometry, and NMR programs.Guodong Chen, PhD, is Principal Scientist in Bioanalytical and Discovery Analytical Sciences at Bristol-Myers Squibb in Princeton, New Jersey. He heads a mass spectrometry group in support of drug discovery as well as development programs in small molecule pharmaceuticals and biologics.
Bibliographische Angaben
- 2008, 400 Seiten, Gebunden, Englisch
- Eds.: Gross, Michael L., Chen, Guodong, Pramanik, Birendra
- Verlag: Wiley & Sons
- ISBN-10: 0813821916
- ISBN-13: 9780813821917
Sprache:
Englisch
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