Molecular Targeting in Oncology

Table of ContentsSection 1 General Strategies for Molecular Targeting in OncologyChapter 1 The Cell Cycle: Therapeutic Targeting of Cell CycleRegulatory Components and Effector Pathways in CancerChad D. Knights and Richard G. PestellChapter 2 mTOR: Properties and TherapeuticsJohn B. Easton and Peter J. HoughtonChapter 3 Ras/Raf/MEK InhibitorsJoseph A. SparanoChapter 4 17AAG: Targeting the Molecular Chaperone Heat Shock Protein 90Len Neckers and Percy IvyChapter 5 The Cancer Epigenome: Can it be targeted for therapy?Sam Thiagalingam and Douglas V. FallerSection 2 Molecular Targeting for Specific Disease SitesChapter 6 Molecular targeting in upper gastrointestinal malignanciesScott WadlerChapter 7 Molecular Targeting of Colorectal Cancer: An Idea Whose TimeHas ComeMark L. Sundermeyer, Alfonso Bellacosa, and Neal J. MeropolChapter 8 Molecular Targeting in Hepatocellular CarcinomaJonathan D. Schwartz. and Josep M. LlovetChapter 9 Molecularly Targeted Therapy in Pancreatic CancerAnupama Goel and Peter KozuchChapter 10 Untargeted Use of Targeted Therapy: A Dilemma in Non-SmallCell Lung CancerCheryl Ho, Angela M. Davies, Primo N. Lara, O. Gautschi, P.C. Mack,Paul H. Gumerlock and David R. GandaraChapter 11 Molecular Targeting in Oncology: Renal Cell CancerOlwen Hahn and Walter StadlerChapter 12 Targeted Therapies for Prostate CancerElisabeth I. Heath and Michael A. CarducciChapter 13 Molecular Targets in Ovarian Cancer and Endometrial CancerNilofer S. Azad, Gisele Sarosy, and Elise C. KohnChapter 14 Targeted Therapy for Breast CancerDeena M. Atieh and Linda T. VahdatChapter 15 MelanomaAkshay Gupta and John M. KirkwoodSection 3 Classes of Drugs for Molecular Targeting in OncologyChapter 16 Antibody Therapy of CancerHossein Borghaei, Liat Binyamin, Igor Astsaturov, and Louis M. WeinerChapter 17 Nucleic Acid Therapies for Cancer TreatmentDan T. Vogl and Alan M. GewirtzChapter 18 Engineering Oncolytic Measles Viruses for Targeted CancerTherapyTakafumi Nakamura and Stephen J.