Molecular Toxicology
(Sprache: Englisch)
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis...
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Produktinformationen zu „Molecular Toxicology “
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expressiong, and analysis of enzymes of biotransformation; and molecular toxicology of aromatic amines, nirosamines, polycyclic aromatic hydrocarbons, chlorinated compounds.
Inhaltsverzeichnis zu „Molecular Toxicology “
- Act One: Toxicity at the Cellular Level
- 1: Toxicology of oxygen
- 2: Covalent Binding of Xenobiotics to DNA and Protein
- 3: DNA Repair
- 4: Chemical Mutagenesis
- 5: Oncogenes, tumor suppressor genes, and mutations in cancer cells
- tumors
- 6: Toxicity, survival, and target theory
- Act Two: Enzymology of Biotransformation
- 7: Cytochrome P450 - Chemical and Biochemical Aspects
- 8: P450: Biological aspects; regulation; genetics
- 9: Biochemistry of glutathione
- 10: Glutathione transferases
- 11: Glutathione and glutathione transferases: Toxicological and pharmacological aspects
- 12: Glucuronidation
- 13: Arylamine N-Acetyltransferase
- 14: Sulfotransferase
- Act Three: Molecular Principles Applied to Specific Toxicants
- 15: Alkylating agents and "mustards"
- 16: Oxidative stress in the erythrocyte: congenital and xenobiotic-induced methemoglobinemia
- 17: Aromatic amines and related toxic compounds
- 18: Polycyclic aromatic hydrocarbon carcinogens
- 19: Acetaminophen
Bibliographische Angaben
- Autoren: P. David Josephy , Bengt Mannervik
- 2006, 2. Aufl., 608 Seiten, mit Abbildungen, Maße: 25,7 x 18,5 cm, Gebunden, Englisch
- Verlag: Oxford University Press
- ISBN-10: 0195176200
- ISBN-13: 9780195176209
Sprache:
Englisch
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