Multi-drug Resistance Gene Polymorphisms in Malay Leukemic Patients
Establishment of the Methods for SNPs Detection in MDR1 Gene
(Sprache: Englisch)
The most frequent single nucleotide polymorphisms (SNPs) of MDR1 gene (in exons 12, 21 and 26) were reported to contribute to the drug resistance in many tumors. The main objectives of this study were to establish the feasible tools for screening of these...
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The most frequent single nucleotide polymorphisms (SNPs) of MDR1 gene (in exons 12, 21 and 26) were reported to contribute to the drug resistance in many tumors. The main objectives of this study were to establish the feasible tools for screening of these three most frequent polymorphisms and to investigate the distribution of these polymorphisms in Malay leukemic patients. DNA samples were collected from Malay patients diagnosed as leukemia was subjected to dHPLC and RFLP analyses. From the results, 25 (25.7%) of the patients showed heterozygous mutation, 7 (6.7%) wild type, while 2 (1.9%) showed homozygous mutation. There was a significant difference in the distribution of polymorphisms between exons 21 and 26 (p
Autoren-Porträt von Badrul Hisham Yahaya, Rosline Hassan, Narazah Yusoff
Yahaya, Badrul HishamBadrul Yahaya received his bachelor's degree in MolecularGenetics from Universiti Kebangsaan Malaysia (UKM) in 2002,Master of Science in Human Genetics from Universiti SainsMalaysia (USM) in 2006 and PhD in Stem Cell/Gene Therapy fromUniversity of Edinburgh, Scotland in 2010. His research interestinvolves cell-based therapy in lung diseases.
Bibliographische Angaben
- Autoren: Badrul Hisham Yahaya , Rosline Hassan , Narazah Yusoff
- 2011, 192 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3843392846
- ISBN-13: 9783843392846
Sprache:
Englisch
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